...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Asian Pacific Journal of Cancer Prevention >Thioredoxin-Interact ing-Pro t e in [TXNIP] and Transglutaminase 2 [TGM2] Expression in Meningiomas of Different Grades and the Role of Their Expression in Meningioma Recurrence and Prognosis
【24h】

Thioredoxin-Interact ing-Pro t e in [TXNIP] and Transglutaminase 2 [TGM2] Expression in Meningiomas of Different Grades and the Role of Their Expression in Meningioma Recurrence and Prognosis

机译：硫氧还蛋白相互作用蛋白在不同级别脑膜瘤中的表达[TXNIP]和转谷氨酰胺酶2 [TGM2]的表达及其在脑膜瘤复发和预后中的作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Meningiomas are common central nervous system (CNS) tumors that account for thirty percent of primary intracranial tumors.. The accuracy of predicting meningioma recurrence and progression is not enough. So, there is a real need for discovering recent factors for identification of the relapse risk, progression rates, which patients will need aggressive treatment and predicting and improving patients’ survival. Thioredoxin-interacting-protein [TXNIP] is an alpha-arrestin-protein family member that is mapped on chromosome 1-q21–22 and is found to participate in cellular redox reactions regulations and control. Transglutaminase 2 (TGM2) is a transglutaminase enzyme family member that is found in many human cells, it may act as an enzyme, a structural protein and also has multiple roles in many cellular activities. Aim of our study: It was to explore the expression of TXNIP, TGM2 and Ki-67 using immunohistochemistry in different pathological grades of meningiomas, and to investigate the relevance between their expressions, clinicopathological criteria, disease recurrence and prognosis of meningioma patients. Methods: we included 50 cases of meningioma of different pathological grades; all patients were managed according to their grade by surgery alone, with radiotherapy or combined modalities. Sections from paraffin blocks prepared from samples of all patients stained by TXNIP, TGM2 and Ki-67 using immunohistochemistry. Results: high expression of TXNIP in 28 out of 50 (56%) cases of meningioma of different pathological grades and was positively correlated with meningioma lower grade, low KI labeling index (p=0.000), adequacy of resection, negatively correlated with high incidence of recurrence after surgery and it was negatively correlated with meningioma higher pathological grades (p=0.000). We detected high expression of TGM2 in 21 out of 50 (42%) cases of meningioma and it was positively correlated with meningioma higher grade (p= 0.002), high KI labeling index (p=0.000), high incidence of recurrence after surgery, progression to higher pathological grades and was negatively correlated with adequacy of resection of meningioma (p=0.000). Conclusion: There is inverse relation between both [TXNIP and TGM2 expression in meningiomas and the combination of decreased expression of TXNIP and increased expression of TGM2 could predict risk of meningioma recurrence and progression in to higher pathological grades.
机译：背景：脑膜瘤是常见的中枢神经系统（CNS）肿瘤，占原发性颅内肿瘤的30％。预测脑膜瘤复发和进展的准确性还不够。因此，真正需要发现最近的因素，以识别复发风险，进展速度，这些患者将需要积极治疗并预测和改善患者的生存。硫氧还蛋白相互作用蛋白[TXNIP]是α-arrestin蛋白家族成员，位于染色体1-q21-22上，被发现参与细胞氧化还原反应的调控。转谷氨酰胺酶2（TGM2）是在许多人类细胞中发现的一种转谷氨酰胺酶家族成员，它可以作为一种酶，一种结构蛋白，并且在许多细胞活动中也具有多种作用。我们的研究目的：使用免疫组织化学方法探讨脑膜瘤不同病理分级中TXNIP，TGM2和Ki-67的表达，并探讨它们的表达，临床病理标准，疾病复发与预后之间的相关性。方法：纳入50例不同病理分级的脑膜瘤病例。所有患者均通过单独手术，放疗或联合方式根据等级进行管理。使用免疫组织化学方法，从所有患者的TXNIP，TGM2和Ki-67染色的样本中制备石蜡块的切片。结果：50例不同病理分级的脑膜瘤病例中有28例（56％）TXNIP高表达，与低度脑膜瘤，低KI标记指数（p = 0.000），切除是否充分，高发生率呈负相关术后复发率与脑膜瘤高病理分级呈负相关（p = 0.000）。我们在50例（42％）脑膜瘤病例中检测到21例TGM2高表达，并且与高级别脑膜瘤（p = 0.002），高KI标记指数（p = 0.000），术后复发率高，进展为更高的病理学等级，与脑膜瘤切除的充分性呈负相关（p = 0.000）。结论：脑膜瘤[TXNIP和TGM2表达之间存在负相关关系，而TXNIP表达降低和TGM2表达升高的组合可预测脑膜瘤复发和发展为更高病理等级的风险。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号