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首页> 外文期刊>Asian Journal of Pharmaceutical and Clinical Research >ANTIBACTERIA ACTIVITY OF PAPUAN ANT-NEST (MYRMECODIA PENDANSL.M. Perry) ETHANOL EXTRACT AGAINST SHIGELLA DYSENTERIAE
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ANTIBACTERIA ACTIVITY OF PAPUAN ANT-NEST (MYRMECODIA PENDANSL.M. Perry) ETHANOL EXTRACT AGAINST SHIGELLA DYSENTERIAE

机译：Papuan蚂蚁（MYRMECODIA PENDANS.M。Perry）乙醇提取物对痢疾痢疾痢疾的抗菌活性

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This research aimed to determine antibacteria activity of ant-nest extract against Shigella dysenteriae and to determine its Minimum Inhibitory Concentration (MIC) – Minimum Bactericidal Concentration (MBC) range of concentration. S . dysenteriae continues to be a major health problem in Indonesia, which usually leads to death, due to diarrhoea and dysentery, predominantly in children below the age of 5. Bacterial invasion of the colonic epithelium leads to severe inflammation together with bacterial dissemination generates abscesses and ulcerations. Myrmecodia pendans , also locally known by indigenous Papuans as ant-nest is native to Southeast Asia. This tropical plant has proven to be rich in bioactive constituents and highly valued as an alternative choice for cancer/tumor treatments and an efficacious herbal drug to prevent and cure diarrhea.Ant-nest dried plant were obtained from Wamena, Papua. The extract was obtained using maceration method with 70% ethanol, from 500.42 g dried plant we can obtain 77.47 g dry extract (15.48% rendement). Phytochemical screening result showed that the ethanol extracts of ant-nest contains metabolites such as alkaloids, flavonoids, tanins, saponins, and steroids/terpenoids. Antibacteria activity test were then performed by using perforated agar method with various extract concentration (10, 20, 40, and 60 % (g/ml)). Largest inhibition zone was shown by 60% extract concentration with 1.74 cm diameter. MIC-MBC concentration determinated by using microdilution method. The result shown that concentration of MIC – MBC lays in range of 14 – 16 % (g/ml).
机译：这项研究旨在确定蚂蚁提取物对痢疾志贺氏菌的抗菌活性，并确定其最低抑菌浓度（MIC）–最低杀菌浓度（MBC）浓度范围。 。痢疾持续存在于印度尼西亚，是主要的健康问题，通常是由于腹泻和痢疾而导致死亡，主要是在5岁以下的儿童中。细菌侵入结肠上皮会导致严重的炎症，并伴随细菌的扩散产生脓肿和溃疡。 。帕尔默人猿（Myrmecodia pendans），也被土著巴布亚人当地称为蚂蚁巢，原产于东南亚。该热带植物已被证明具有丰富的生物活性成分，并被高度评价为癌症/肿瘤治疗的替代选择，以及一种有效的预防和治疗腹泻的草药。蚂蚁巢干燥植物获自巴布亚的瓦梅纳。提取物是用浸渍法用70％乙醇制得，从500.42 g干燥植物中，我们可以得到77.47 g干提取物（15.48％沉淀物）。植物化学筛选结果表明，蚂蚁巢的乙醇提取物中含有生物碱，类黄酮，单宁，皂角苷和类固醇/类萜等代谢产物。然后使用穿孔琼脂法以各种提取物浓度（10％，20％，40％和60％（g / ml））进行抗菌活性测试。 60％的提取物浓度（直径1.74厘米）显示出最大的抑制区。 MIC-MBC浓度采用微量稀释法测定。结果表明，MIC – MBC的浓度范围为14 – 16％（g / ml）。

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