...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Asian Journal of Pharmaceutical and Clinical Research >BIODEGRADABLE POLYMER: A NOVEL PHARMACEUTICAL CARRIER FOR SUSTAINED RELEASE OF METRONIDAZOLE
【24h】

BIODEGRADABLE POLYMER: A NOVEL PHARMACEUTICAL CARRIER FOR SUSTAINED RELEASE OF METRONIDAZOLE

机译：生物可降解聚合物：新型甲硝唑缓释药物载体

获取原文
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: To optimize and evaluate the formulation of metronidazole (MT)-loaded chitosan microspheres and to investigate the efficiency of biodegradable polymer in developing sustained release formulation of MT to prolong the action of drug. Methods: MT microspheres were prepared using emulsion cross-linking method. Polymer-drug compatibility study was done using Fourier transform infrared. Physical characteristics were evaluated by particle size,SEM, flow properties etc. In vitro studies for evaluating drug release for MT-loaded chitosan microspheres were done by dissolution study. Results: Particle size of the formulated microspheres was found to be within the range of 110-130 μm. Flow properties of F1-F7 such as angle of repose, bulk density, and tapped density were found to be within limits. Drug entrapment efficiency was found to be better for all the formulations within the range of 74.82-84.32% w/w. Drug loading capacity was found to be in the range of 56-83.2% w/v. In vitro drug release was found to be in the range of 81.32-96.23% w/v. Conclusion: In spite of all the above results, we conclude that F5 formulation was optimized depending on the data obtained from the drug loading capacity and percentage drug release studies. F5 formulation is formulated with drug-polymer ratio 1:2 with 1% of di octyl sodium sulfo succinate and 8 ml of glutaraldehyde as a cross-linking agent.
机译：目的：优化和评估甲硝唑（MT）负载的壳聚糖微球的配方，并研究可生物降解的聚合物在开发MT缓释制剂以延长药物作用方面的效率。方法：采用乳液交联法制备MT微球。聚合物-药物相容性研究是使用傅立叶变换红外进行的。通过粒度，SEM，流动性质等评价物理特性。通过溶解研究完成了用于评价MT负载的壳聚糖微球的药物释放的体外研究。结果：发现配制的微球的粒度在110-130μm的范围内。发现F1-F7的流动特性（如休止角，堆积密度和拍击密度）在极限范围内。发现所有制剂在74.82-84.32％w / w的范围内药物截留效率更好。发现载药量在56-83.2％w / v的范围内。发现体外药物释放在81.32-96.23％w / v的范围内。结论：尽管有上述所有结果，但我们得出结论，F5制剂是根据从药物载量和药物释放百分比研究获得的数据进行了优化的。 F5制剂以1：2的药物/聚合物比例，1％的磺基琥珀酸二辛酯钠和8 ml的戊二醛作为交联剂配制而成。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号