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首页> 外文期刊>Annals of Indian Academy of Neurology >Role of Physical Activity in Parkinson's Disease
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Role of Physical Activity in Parkinson's Disease

机译：体育活动在帕金森氏病中的作用

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Parkinson's disease (PD) is common, age-dependent neurodegenerative disorder caused by a severe loss of the nigrostriatal dopaminergic neurons. Given the projected increase in the number of people with PD over the coming decades, interventions aimed at minimizing morbidity and improve quality of life are crucial. There is currently no fully proven pharmacological therapy that can modify or slow the disease progression. Physical activity (PA) can complement pharmacological therapy to manage the inherent decline associated with the disease. The evidence indicates that upregulation of neurotrophins and nerve growth factors are potentially critical mediators of the beneficial effects associated with PA. Accumulating evidence suggests that patients with PD might benefit from PA in a number of ways, from general improvements in health to disease-specific effects and potentially, disease-modifying effects. Various forms of PA that have shown beneficial effects in PD include – aerobic exercises, treadmill training, dancing, traditional Chinese exercise, yoga, and resistance training. In this review, we explored available research that addresses the impact of exercise and PA on PD. The original articles with randomized control trials, prospective cohort studies, longitudinal studies, meta-analysis, and relevant review articles from 2005 to 2017 were selected for the present review. Many gaps remain in our understanding of the most effective exercise intervention for PD symptoms, the mechanisms underlying exercise-induced changes and the best way to monitor response to therapy. However, available research suggests that exercise is a promising, cost-effective, and low-risk intervention to improve both motor and nonmotor symptoms in patients with PD. Thus, PA should be prescribed and encouraged in all PD patients.
机译：帕金森氏病（PD）是常见的，年龄依赖性的神经退行性疾病，由黑质纹状体多巴胺能神经元的严重丧失引起。鉴于在未来几十年中，PD患者的数量预计会增加，因此旨在最大程度降低发病率和改善生活质量的干预措施至关重要。当前，尚无可证明可以改变或减慢疾病进展的药物疗法。体力活动（PA）可以补充药物治疗，以控制与疾病相关的内在衰退。有证据表明，神经营养蛋白和神经生长因子的上调是与PA相关的有益作用的潜在关键介质。越来越多的证据表明，PD患者可以通过多种方式从PA中受益，从健康的全面改善到疾病特异性作用以及潜在的疾病缓解作用。在PD中显示出有益效果的各种形式的PA，包括：有氧运动，跑步机训练，舞蹈，中国传统运动，瑜伽和阻力训练。在本文中，我们探讨了可解决运动和PA对PD的影响的现有研究。选择2005年至2017年间随机对照试验，前瞻性队列研究，纵向研究，荟萃分析和相关综述文章的原始文章作为本评价。在我们对PD症状最有效的运动干预，运动引起的变化的基础机制以及监测对治疗反应的最佳方法的理解上，仍有许多差距。但是，现有研究表明，运动是改善PD患者运动和非运动症状的一种有希望的，具有成本效益的低风险干预措施。因此，所有PD患者均应开具PA并予以鼓励。

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