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首页> 外文期刊>Annals of Intensive Care >Nasal high flow in management of children with status asthmaticus: a retrospective observational study
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Nasal high flow in management of children with status asthmaticus: a retrospective observational study

机译：鼻高流量治疗小儿哮喘病的回顾性观察研究

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BackgroundAsthma is the most common obstructive airway disease in children and adults. Nasal high flow (NHF) is a recent device that is now used as a primary support for respiratory distress. Several studies have reported use of NHF as a respiratory support in status asthmaticus; however, there are no data to recommend such practice. We therefore conducted this preliminary study to evaluate NHF therapy for children with status asthmaticus admitted to our PICU in order to prepare a multicentre randomized controlled study. ResultsBetween November 2009 and January 2014, 73 patients with status asthmaticus were admitted to the PICU, of whom 39 (53%) were treated with NHF and among these 10 (26%) presented severe acidosis at admission (pH p p p =?0.009) and median [IQR] pCO2 decreased significantly (7.27?kPa [6.84–7.91 vs. 5.85?kPa [5.56–6.11], p =?0.007). No patient was intubated. ConclusionThis retrospective study showed the feasibility and safety of NHF in children with severe asthma. Blood gas and clinical parameters were significantly improved during the first 24?h. NHF failed in only two patients, and none required invasive ventilation.
机译：背景哮喘是儿童和成人中最常见的阻塞性气道疾病。鼻高流量（NHF）是一种新近使用的设备，现已用作呼吸窘迫的主要支持物。几项研究报道了在患有哮喘的哮喘患者中使用NHF作为呼吸支持。但是，没有数据可以推荐这种做法。因此，我们进行了这项初步研究，以评估NHF治疗接受PICU治疗的患有哮喘的儿童的情况，从而准备了一项多中心随机对照研究。结果在2009年11月至2014年1月之间，有73例哮喘状态的患者被纳入PICU，其中39例（53％）接受了NHF治疗，其中10例（26％）入院时出现严重酸中毒（pH ppp =？0.009），中位数[IQR] pCO 2 显着下降（7.27？kPa [6.84-7.91; 5.85？kPa [5.56-6.11]，p =？0.007）。没有患者被插管。结论这项回顾性研究显示了NHF治疗严重哮喘儿童的可行性和安全性。在最初的24小时内，血气和临床参数得到了显着改善。 NHF仅在2例患者中失败，并且都不需要有创通气。

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