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首页> 外文期刊>Annals of King Edward Medical University. >Importance of Routine Histopathology of Gallbladder after Elective Cholecystectomy for Gallstones
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Importance of Routine Histopathology of Gallbladder after Elective Cholecystectomy for Gallstones

机译：胆囊结石择期胆囊切除术后胆囊常规组织病理学的重要性

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Introduction:????Gallstones are the hard deposits in the gallbladder, which is a sac a€“ like organ lying on the inferior surface of liver in the right upper quadrant of abdomen. Cholecystectomy is the first line surgical procedure to manage symptomatic gallstone. Carcinoma gallbladder carries worst prognosis of all cancer mortality and seen in patients with chronic cholecystitis due to cholelithiasis. The purpose of conductingthis study was to highlight the fact, that the histopathology of the gallbladder in Pakistan is only restricted to those specimens, which are associated with macroscopic abnormalities.Objective:????The frequency of gallbladder carcinoma in routine histopathology after elective Cholecystectomy for gallstones who did not show any macroscopic findings preoperatively.Material and Methods:????This cross sectional study of 250 patients of both gender aged between 18 a€“ 60 years was conducted in surgical OPD/North Surgical Unit of Mayo Hospital, Lahore in one year duration from 01-01-2014 to 31-12-2014. The non-probability purposive sampling technique was used in this study. Informed consent was taken from all the patients. Their demographics like name, age, gender and address were noted. Open / laparoscopic cholecystectomy was performed depending upon patienta€?s choice. All gallbladder specimens, those with no obvious gross abnormalities were sent for histopathology (Gross findings, histopathological diagnosis). All data was recorded on a pre-designed proforma and analyzed using SPSS version 20. Mean and standard deviation were used to express the continuous variables like age, stone size and duration of disease. All qualitative variables like gender, number of stones and gallbladder carcinoma were presented in the form of frequency and percentages. Stratification was done for duration of disease, number of stone, size of stone and gender to address effect modifiers. Post stratification chi-square test was applied keeping P-value a‰¤ 0.05 as significant.Results:????In this study the mean age of the patients was 39.52 ?± 12.38 years. Among 250 patients, 75 (30%) were males and 175 (70%) females. The mean duration of disease was 5.61 ?± 2.75 months. Gallbladder carcinoma on routine histopathology after elective Cholecystectomy was observed in 18 (7.2%) patients whereas 232 (92.8%) patients did not have gallbladder carcinoma. All of the 18 patients who had carcinoma were females which showed a highly significant difference (p 0.05).Conclusion:????Although the frequency of gallbladder carcinoma on histopathology is low, but not negligible, therefore histopathology of gallbladder specimen is necessary to rule out carcinoma.
机译：简介：胆结石是胆囊中的硬性沉积物，是位于腹部右上腹肝下表面的一个囊状器官。胆囊切除术是处理有症状胆结石的一线手术方法。胆囊癌的所有癌症死亡预后最差，在因胆石症引起的慢性胆囊炎患者中见到。进行这项研究的目的是要强调一个事实，即巴基斯坦胆囊的组织病理学仅局限于那些与宏观异常有关的标本。目的：选择性胆囊切除术后常规胆囊癌的胆囊癌发生率材料和方法：这项横断面研究在Mayo医院的外科OPD / North Surgical Unit进行，共250例年龄在18至60岁之间的性别患者进行了横断面研究，拉合尔的有效期从2014年1月1日到2014年12月31日。在这项研究中使用了非概率目的抽样技术。所有患者均获得知情同意。记录了他们的人口统计资料，例如姓名，年龄，性别和地址。根据患者的选择进行开腹/腹腔镜胆囊切除术。所有没有明显异常的胆囊标本都送去进行组织病理学检查（总发现，组织病理学诊断）。所有数据均记录在预先设计的形式表中，并使用SPSS 20版进行分析。均值和标准差用于表示连续变量，例如年龄，结石大小和疾病持续时间。所有定性变量（如性别，结石数目和胆囊癌）均以频率和百分比的形式显示。对疾病的持续时间，结石数量，结石大小和性别进行分层，以解决效果修饰剂。应用分层后卡方检验，使P值≥0.05为显着性。结果：在本研究中，患者的平均年龄为39.52±±12.38岁。在250名患者中，男性（75％（30％））和175（70％）女性。平均病程为5.61±2.75个月。选择性胆囊切除术后胆囊癌的常规组织病理学观察到18例（7.2％），而232例（92.8％）没有胆囊癌。结论：18例胆囊癌患者均为女性，差异有极显着性意义（P <0.05）。结论：尽管胆囊癌的组织学检查频率较低，但可以忽略不计，因此胆囊标本的组织病理学检查是必要的。排除癌。

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