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首页> 外文期刊>Arquivos Brasileiros de Oftalmologia >Epidemiologic Study of Retinoblastoma in Recife, Pernambuco - Brazil: January 1985 - July 1997
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Epidemiologic Study of Retinoblastoma in Recife, Pernambuco - Brazil: January 1985 - July 1997

机译：伯南布哥累西腓视网膜母细胞瘤的流行病学研究：1985年1月-1997年7月

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Background: Retinoblastoma is by far the most frequent malignant intraocular tumor of childhood. This study was performed to characterize the clinical, diagnostic, treatment and prognostic aspects in patients with retinoblastoma in three reference centers for this pathology in the city of Recife, Pernambuco - Brazil. Methods: A consecutive series of 85 patients with retinoblastoma was reviewed. The authors selected 66 patients (77.6%) that fulfilled the inclusion criteria for these study. Results: Of a total of 66 patients with retinoblastoma, 4.5% had a previous history of the disease in the family. Males were more affected than females at a ratio (male/female) of 1.12. The mean age of appearance of the first symptoms was 23.8 months, with leukocoria and ocular hyperemia being the most frequent. The mean age at time of diagnosis was 31.7 months and for surgical treatment 32.8 months. The right eye was affected in 42.4% of the cases and the left was involved in 37.9% of cases. The tumor was unilateral in 80.3% and bilateral in 19.7% of the cases. There was extraocular involvement in 62.1%, and it was intraocular in 37.9% of the patients. Treatment was surgery combined with chemotherapy in 47.0% of the patients. 27.3% of the patients died and 19.7% abandoned the treatment. Conclusions: The data on the epidemiology of retinoblastoma found in our city resembles that of other developing countries, concerning the epidemioloy of retinoblastoma.
机译：背景：视网膜母细胞瘤是迄今为止儿童期最常见的恶性眼内肿瘤。这项研究的目的是在巴西伯南布哥累西腓市的三个病理学参考中心，对视网膜母细胞瘤患者的临床，诊断，治疗和预后进行特征分析。方法：对连续系列的85例视网膜母细胞瘤患者进行了回顾。作者选择了符合这些研究纳入标准的66名患者（77.6％）。结果：在总共66例视网膜母细胞瘤患者中，有4.5％的患者曾有家族病史。男性比女性受影响的比例更大（男性/女性）为1.12。首次出现症状的平均年龄为23.8个月，其中白斑和眼部充血最为常见。诊断时的平均年龄为31.7个月，而手术治疗的平均年龄为32.8个月。右眼受累的占42.4％，左眼受累的占37.9％。肿瘤为单侧的占80.3％，双侧的占19.7％。眼外受累率为62.1％，眼内受累率为37.9％。在47.0％的患者中，手术与化学疗法相结合。 27.3％的患者死亡，19.7％的患者放弃治疗。结论：在我们城市发现的视网膜母细胞瘤的流行病学数据与其他发展中国家相似，涉及视网膜母细胞瘤的流行病学。

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