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The Role of Hyaluronan and CD44 in the Pathogenesis of Lupus Nephritis

机译：透明质酸和CD44在狼疮性肾炎发病中的作用

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Systemic lupus erythematosus (SLE) is a prototype autoimmune disease that affects multiorgan systems. Lupus nephritis is one of the most severe manifestations of SLE whereby immune-mediated inflammation can lead to permanent damage within the glomerular, tubulo-interstitial, and vascular compartments of the kidney, resulting in acute or chronic renal failure. The mechanisms that regulate host inflammatory responses and tissue injury are incompletely understood. Accumulating evidence suggests that hyaluronan and its interaction with its cell surface receptor CD44 plays an important role in mediating pathogenic mechanisms in SLE. This paper discusses the putative mechanisms through which hyaluronan and CD44 contribute to the pathogenesis of SLE, with particular emphasis on lupus nephritis.
机译：系统性红斑狼疮（SLE）是一种影响多种器官系统的原型自身免疫性疾病。狼疮性肾炎是SLE的最严重表现之一，免疫介导的炎症可导致肾脏的肾小球，肾小管间质和血管腔内永久性损伤，从而导致急性或慢性肾功能衰竭。调节宿主炎症反应和组织损伤的机制尚未完全了解。越来越多的证据表明，透明质酸及其与细胞表面受体CD44的相互作用在介导SLE的致病机制中起着重要作用。本文讨论了透明质酸和CD44促成SLE发病机理的推测机制，特别是狼疮性肾炎。

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