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首页> 外文期刊>Autoimmune diseases >Increased Whole Blood Viscosity Is Associated with the Presence of Digital Ulcers in Systemic Sclerosis: Results from a Cross-Sectional Pilot Study
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Increased Whole Blood Viscosity Is Associated with the Presence of Digital Ulcers in Systemic Sclerosis: Results from a Cross-Sectional Pilot Study

机译：全血粘度增加与系统性硬化症中数字溃疡的存在相关：一项跨部门研究的结果

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Objective. To investigate the role of whole blood viscosity in digital ulcer (DU) development in patients with diffuse and limited Systemic sclerosis. Methods. A convenience sample of patients with Systemic sclerosis (SSc) was selected from the adult Rheumatology clinic at the University of Chicago. The study group consisted of patients with SSc (with ulcers present, a history of ulcers, and no ulcers); the control group consisted of matched healthy Rheumatology clinic staff. WBV was measured using a scanning capillary viscometer at different shear rates (1a??1000a??1/s). Results. Whole blood viscosity as measured by a scanning capillary viscometer was increased in patients with SSc compared to healthy controls (). Additionally, patients with present DU had significantly higher whole blood viscosity when compared to patients with a history of DU and patients with no history of DU (). These findings were most pronounced at lower shear rates between 1 and 10a??1/s. Conclusion. Whole blood viscosity might be a contributing factor in DU development in patients with SSc. Further studies with larger patient cohorts are required to fully evaluate how increased WBV contributes to the development of DU and whether the currently available treatment options improve the microcirculation by influencing WBV.
机译：目的。调查全血粘度在弥漫性和局限性系统性硬化症患者的数字溃疡（DU）发展中的作用。方法。从芝加哥大学的成人风湿病诊所选择了系统性硬化症（SSc）患者的便利样本。研究组由SSc患者组成（有溃疡，有溃疡病史，无溃疡）。对照组由相匹配的健康风湿病诊所人员组成。用扫描毛细管粘度计在不同的剪切速率（1a≤1000a≤1/ s）下测量WBV。结果。与健康对照相比，SSc患者通过扫描毛细管粘度计测得的全血粘度增加。此外，与有DU病史和无DU病史的患者相比，具有DU病史的患者的全血粘度明显更高。这些发现在较低的剪切速率（1和10a？1/1 / s）之间最为明显。结论。全血粘度可能是SSc患者DU发生的一个促成因素。需要对更大的患者队列进行进一步研究，以全面评估增加的WBV如何促进DU的发展，以及当前可用的治疗选择是否通过影响WBV改善微循环。

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