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首页> 外文期刊>Autoimmune diseases >Relationships among Antibodies against Extractable Nuclear Antigens, Antinuclear Antibodies, and Autoimmune Diseases in a Brazilian Public Hospital
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Relationships among Antibodies against Extractable Nuclear Antigens, Antinuclear Antibodies, and Autoimmune Diseases in a Brazilian Public Hospital

机译：巴西公立医院中针对可提取核抗原，抗核抗体和自身免疫性疾病的抗体之间的关系

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One characteristic of autoimmune diseases (ADs) is the production of autoantibodies for extractable nuclear autoantigens, which may aid in the discrimination of the different types of autoimmune diseases and is related to different antinuclear antibody (ANA) patterns. The present study verified the profile of patient samples tested for extractable nuclear antigens (ENA) antibodies in a public hospital and correlated the ENA results with ANA patterns and patient diagnoses. The study reviewed data in the medical records of patients who underwent anti-ENA tests at a public hospital in the West of the State of Paraná from February 2011 to January 2017. Patients were classified according to age, ethnicity, gender, anti-ENA test results, ANA results, and the presence or absence of AD. Thirty-six (20.9%) samples of the 172 anti-ENA tests were positive, seven (4.1%) samples were undetermined, and 129 (75%) exhibited negative results. The ANA reagent was found in 84.3% of the anti-ENA-positive samples. The anti-SSA/Ro autoantibody exhibited the highest frequency in the group, 41.7% (15/36). The most common pattern was nuclear fine speckled, which was found in 24.3% of the samples. The association results indicated a significant relationship between ANA titer and diagnosis in the anti-ENA- and ANA-positive patients. The anti-ENA-negative patients were diagnosed with an AD in 35% (45/129) of the cases, and 75% (27/36) of the anti-ENA-positive patients were diagnosed with an AD. Systemic lupus erythematosus and scleroderma were the most common pathologies in the antigen-positive patients. The anti-ENA test is a good marker to aid in the complex clinical diagnosis of patients with autoimmune diseases.
机译：自身免疫性疾病（ADs）的一个特征是可提取核自身抗原的自身抗体的产生，这可能有助于区分不同类型的自身免疫性疾病，并且与不同的抗核抗体（ANA）模式有关。本研究验证了在公立医院中测试的可提取核抗原（ENA）抗体的患者样品的概况，并将ENA结果与ANA模式和患者诊断相关联。该研究回顾了2011年2月至2017年1月在巴拉那州西部的一家公立医院接受抗ENA测试的患者的病历数据。按年龄，种族，性别，抗ENA测试对患者进行分类结果，ANA结果以及是否存在AD。 172个抗ENA测试中有36个（20.9％）样品为阳性，未确定的样品为7（4.1％），有129个（75％）样品为阴性。在84.3％的抗ENA阳性样品中发现了ANA试剂。抗SSA / Ro自身抗体在该组中显示最高频率，为41.7％（15/36）。最常见的模式是核精细斑点，在24.3％的样品中发现。关联结果表明，ANA效价与抗ENA和ANA阳性患者的诊断之间存在显着关系。在35％（45/129）的病例中，抗ENA阴性的患者被诊断为AD，而在抗ENA阳性的患者中，有75％（27/36）被诊断为AD。系统性红斑狼疮和硬皮病是抗原阳性患者中最常见的病理。抗ENA检测是一种良好的标记物，有助于自身免疫性疾病患者的复杂临床诊断。

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