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首页> 外文期刊>IBRO Reports >BDNF trafficking and signaling impairment during early neurodegeneration is prevented by moderate physical activity
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BDNF trafficking and signaling impairment during early neurodegeneration is prevented by moderate physical activity

机译：适度的体育锻炼可预防早期神经变性期间的BDNF转运和信号传导障碍

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Physical exercise can attenuate the effects of aging on the central nervous system by increasing the expression of neurotrophins such as brain-derived neurotrophic factor (BDNF), which promotes dendritic branching and enhances synaptic machinery, through interaction with its receptor TrkB. TrkB receptors are synthesized in the cell body and are transported to the axonal terminals and anchored to plasma membrane, through SLP1, CRMP2 and Rab27B, associated with KIF1B. Retrograde trafficking is made by EDH-4 together with dynactin and dynein molecular motors. In the present study it was found that early neurodegeneration is accompanied by decrease in BDNF signaling, in the absence of hyperphosphorylated tau aggregation, in hippocampus of 11 months old Lewis rats exposed to rotenone. It was also demonstrated that moderate physical activity (treadmill running, during 6 weeks, concomitant to rotenone exposure) prevents the impairment of BDNF system in aged rats, which may contribute to delay neurodegeneration. In conclusion, decrease in BDNF and TrkB vesicles occurs before large aggregate-like p-Tau are formed and physical activity applied during early neurodegeneration may be of relevance to prevent BDNF system decay. Highlights ? There is decrease in BDNF signaling in absence of protein inclusions in hippocampus of aged rats. ? Trafficking of BDNF/TrkB decreases in hippocampal cells in the absence of pTau. ? Moderate physical activity prevents the impairment of BDNF system in aged rats.
机译：体育锻炼可以通过增加神经营养蛋白（例如脑源性神经营养因子（BDNF））的表达来减轻衰老对中枢神经系统的影响，该蛋白通过与其受体TrkB的相互作用促进树突状分支并增强突触机制。 TrkB受体在细胞体内合成，并通过与KIF1B相关的SLP1，CRMP2和Rab27B转运到轴突末端并锚定在质膜上。 EDH-4与动力蛋白和动力蛋白分子马达一起进行逆行运输。在本研究中，发现在暴露于鱼藤酮的11个月大的Lewis大鼠海马中，在没有高磷酸化tau聚集的情况下，早期神经变性伴随着BDNF信号的减少。研究还表明，适度的体育锻炼（在跑步机上跑步6周，并伴随鱼藤酮暴露）可以防止衰老大鼠的BDNF系统受损，这可能有助于延缓神经退行性变。总之，BDNF和TrkB囊泡的减少在大的聚集体样p-Tau形成之前就已经发生，并且在早期神经退行性变期间施加的体力活动可能与防止BDNF系统衰变有关。强调 ？在老年大鼠海马中不存在蛋白质夹杂物时，BDNF信号传导减少。 ？在不存在pTau的情况下，海马细胞中BDNF / TrkB的运输减少。 ？适度的体育锻炼可防止衰老大鼠BDNF系统受损。

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