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首页> 外文期刊>IBRO Reports >Xenon pressure dependence on the synchronized burst inhibition of rat cortical neuronal network cultured on multi-electrode arrays
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Xenon pressure dependence on the synchronized burst inhibition of rat cortical neuronal network cultured on multi-electrode arrays

机译：氙气压力对多电极阵列上培养的大鼠皮质神经网络同步爆发抑制的依赖性

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Mature rat cortical neuronal networks cultured on multi-electrode arrays (MEAs) are known to show spontaneous synchronized bursts accompanied by independent single spikes. The spontaneous synchronized bursts can be inhibited by Xe gas. In this study, we adjust the Xe gas pressure to control the amount of Xe in a neuron-cultured MEA medium. We show that the synchronized bursts cease completely within several minutes by applying Xe gas at partial pressures above 0.3MPa. After depressurizing and purging with fresh air, the synchronized bursts recover to their original frequency. Thus, we confirmed that Xe acts as a network-activity inhibitor of the cultured neuronal network on MEAs. But below 0.3MPa, the synchronized bursts are inhibited only partially, depending on the Xe partial pressure. Based on the partial-pressure influence on the change of the neuronal network activities, we find the critical concentration of Xe for the inhibition effect to be approximately 9.5mM, a value above which more than 90% of the synchronized burst activity is inhibited. Further systematic observations with Xe-air mixed gases show that pressurized air with a small amount of Xe suppresses the inhibition of synchronized bursts, suggesting an air component that can accelerate the synchronized bursts.
机译：已知在多电极阵列（MEA）上培养的成熟大鼠皮质神经元网络会显示出自发的同步爆发，并伴有独立的单个尖峰。 Xe气体可以抑制自发的同步突发。在这项研究中，我们调整氙气压力以控制神经元培养的MEA培养基中氙气的量。我们显示，通过在0.3MPa以上的分压下施加氙气，同步脉冲在几分钟内完全停止。减压并用新鲜空气吹扫后，同步的突发恢复到其原始频率。因此，我们证实Xe充当MEAs上培养的神经元网络的网络活性抑制剂。但低于0.3MPa时，取决于Xe分压，同步脉冲仅被部分抑制。基于分压对神经元网络活动变化的影响，我们发现抑制作用的临界Xe浓度约为9.5mM，高于该浓度时，超过90％的同步爆发活动被抑制。对Xe-空气混合气体的进一步系统观察表明，含有少量Xe的压缩空气会抑制同步脉冲的抑制，这表明空气成分会加速同步脉冲。

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