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首页> 外文期刊>IBRO Reports >Effects of an early life experience on rat brain cannabinoid receptors in adolescence and adulthood
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Effects of an early life experience on rat brain cannabinoid receptors in adolescence and adulthood

机译：早期生活经验对青春期和成年期大鼠脑大麻素受体的影响

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Neonatal handling is an experimental model of early life experience associated with resilience in later life challenges, altering the ability of animals to respond to stress. The endocannabinoid system of the brain modulates the neuroendocrine and behavioral effects of stress, while this system is also capable of being modulated by stress exposure itself. The present study has addressed the question of whether neonatal handling in rats could affect cannabinoid receptors, in an age- and sex-dependent manner, usingin situhybridization and receptor binding techniques. Different effects of neonatal handling were observed in adolescent and adult brain on CB1 receptor mRNA and [3H]CP55,940 binding levels, which in some cases were sexually dimorphic. Neonatal handling interfered in the developmental trajectories of CB1 receptor mRNA levels in striatum and amygdaloid nuclei, as well as of [3H]CP55,940 binding levels in almost all regions studied. Adult handled rats showed reduced [3H]CP55,940 binding levels in the prefrontal cortex, striatum, nucleus accumbens and basolateral amygdala, while binding levels in prefrontal cortex of adolescent handled rats were increased. Finally, handling resulted in decreases in female [3H]CP55,940 binding levels in the striatum, nucleus accumbens, CA3 and DG of dorsal hippocampus and basolateral amygdala. Our results suggest that a brief and repeated maternal separation during the neonatal period induces changes on cannabinoid receptors differently manifested between adolescence and adulthood, male and female brain, which could be correlated to their stress response.
机译：新生儿处理是一种早期生活经验的实验模型，与以后的生活挑战中的适应能力相关，从而改变了动物对压力的反应能力。大脑的内源性大麻素系统调节压力的神经内分泌和行为效应，而该系统也可以通过自身的压力暴露来调节。本研究使用原位杂交和受体结合技术解决了大鼠新生处理是否能够以年龄和性别依赖性的方式影响大麻素受体的问题。在青少年和成人大脑中，观察到新生儿处理对CB1受体mRNA和[3H] CP55,940结合水平（在某些情况下是两性性的）的不同影响。新生儿处理干扰了纹状体和杏仁核中CB1受体mRNA水平以及几乎所有研究区域的[3H] CP55,940结合水平的发展轨迹。成年处理的大鼠显示前额皮质，纹状体，伏隔核和基底外侧杏仁核中的[3H] CP55,940结合水平降低，而青春期处理的大鼠前额皮质中的[3H] CP55,940结合水平降低。最后，处理导致雌性[3H] CP55,940在背侧海马和基底外侧杏仁核的纹状体，伏隔核，CA3和DG中的结合水平降低。我们的研究结果表明，新生儿期间短暂而反复的母体分离会诱导大麻素受体的变化，这种变化在青春期和成年期，男女大脑之间表现出不同，这可能与其压力反应有关。

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