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首页> 外文期刊>IBRO Reports >The relationship between amplitude of low frequency fluctuations and gray matter volume of the mirror neuron system: Differences between low disability multiple sclerosis patients and healthy controls
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The relationship between amplitude of low frequency fluctuations and gray matter volume of the mirror neuron system: Differences between low disability multiple sclerosis patients and healthy controls

机译：低频波动幅度与镜像神经元系统灰质体积之间的关系：低残疾多发性硬化症患者与健康对照组之间的差异

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The study of the relationship between function and structure of the brain could be particularly interesting in neurodegenerative diseases like multiple sclerosis (MS).The aim of the present work is to identify differences of the amplitude of low frequency fluctuations (ALFF) in the mirror neuron system (MNS) between MS patients and healthy controls and to study the relationship between ALFF and the gray matter volume (GMV) of the regions that belong to the MNS.Relapsing-remitting MS patients with minor disability were compared to healthy controls (HC) using resting-state functional magnetic resonance imaging (fMRI), anatomic T1 weighted images and diffusion tensor imaging (DTI). Region of interest (ROI) analyses was performed in the MNS regions.A decrease of ALFF in MS patients was observed in the left inferior frontal gyrus (IFG). Furthermore, a correlation between ALFF in the IFG and the GMV of the left inferior parietal lobule (IPL) was identified. This relationship was different for MS patients than for HC, which may be associated with changes in diffusivity measures which were impaired in MS patients.MS patients with low disability may show ALFF differences in the MNS without clinical correspondence. This functional difference may be associated with cortical and subcortical changes related to the disease.
机译：在多发性硬化症（MS）等神经退行性疾病中，研究大脑的功能与结构之间的关系可能特别有趣。本工作的目的是确定镜像神经元的低频波动幅度（ALFF）的差异MS患者和健康对照之间的系统（MNS），研究ALFF与MNS区域的灰质体积（GMV）之间的关系。将患有轻度残疾的MS复发缓解型患者与健康对照（HC）进行比较使用静止状态功能磁共振成像（fMRI），解剖T1加权图像和扩散张量成像（DTI）。在MNS区域进行了感兴趣区域（ROI）分析.MS患者的左下额回（IFG）观察到ALFF降低。此外，还确定了IFG中的ALFF与左下顶叶（IPL）的GMV之间的相关性。 MS患者与HC患者之间的这种关系是不同的，这可能与MS患者中弥散性指标的改变有关。低残疾MS患者的MNS可能显示ALFF差异而无临床对应。这种功能差异可能与与疾病相关的皮质和皮质下改变有关。

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