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Genetics of Glioblastoma in Moroccan population: Review of literature

机译：摩洛哥人胶质母细胞瘤的遗传学：文献综述

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Glioblastoma is the most aggressive malignant type of central nervous system tumors. The literature review revealed that the most common genetic abnormalities in primary and secondary glioblastomas are IDH1 / 2 mutations, p53 mutations, and overexpression of EGFR.To our knowledge, this is the first Moroccan study to provide a global picture of genetic studies performed on Moroccan patients to describe genetic markers and their frequency in our population.An in-depth research in ScienceDirect and Pubmed on glioblastoma articles treated in Morocco, this research is based on the following keywords: glioblastoma in Morocco, primary glioblastoma in Morocco, secondary glioblastoma in Morocco.We found only three research articles on genomic alteration of IDH1 / 2, p53 and EGFR expression. The frequency of these gene mutations in our population was similar to those reported from other populations.Additional molecular studies need to be performed on other genes to describe other genetic markers in the Moroccan population.
机译：胶质母细胞瘤是中枢神经系统肿瘤中最具侵袭性的恶性类型。文献综述显示，原发性和继发性胶质母细胞瘤最常见的遗传异常是IDH1 / 2突变，p53突变和EGFR过度表达。据我们所知，这是第一项摩洛哥研究，提供了对摩洛哥进行的遗传研究的全球概况患者描述基因标记及其频率。ScienceDirect和Pubmed对摩洛哥治疗的胶质母细胞瘤文章进行了深入研究，该研究基于以下关键词：摩洛哥的胶质母细胞瘤，摩洛哥的原发性胶质母细胞瘤，摩洛哥的继发性胶质母细胞瘤我们只发现了三篇有关IDH1 / 2，p53和EGFR表达的基因组改变的研究文章。这些基因突变在我们人群中的发生频率与其他人群所报道的相似。需要对其他基因进行其他分子研究，以描述摩洛哥人群中的其他遗传标记。

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