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首页> 外文期刊>IBRO Reports >Neuromodulation with electromagnetic stimulation for seizure suppression: From electrode to magnetic coil
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Neuromodulation with electromagnetic stimulation for seizure suppression: From electrode to magnetic coil

机译：带有电磁刺激的神经调节可抑制癫痫发作：从电极到电磁线圈

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Non-invasive brain tissue stimulation with a magnetic coil provides several irreplaceable advantages over that with an implanted electrode, in altering neural activities under pathological situations. We reviewed clinical cases that utilized time-varying magnetic fields for the treatment of epilepsy, and the safety issues related to this practice. Animal models have been developed to foster understanding of the cellular/molecular mechanisms underlying magnetic control of epileptic activity. These mechanisms include (but are not limited to) (1) direct membrane polarization by the magnetic field, (2) depolarization blockade by the deactivation of ion channels, (3) alteration in synaptic transmission, and (4) interruption of ephaptic interaction and cellular synchronization. Clinical translation of this technology could be improved through the advancement of magnetic design, optimization of stimulation protocols, and evaluation of the long-term safety. Cellular and molecular studies focusing on the mechanisms of magnetic stimulation are of great value in facilitating this translation.
机译：在病理情况下改变神经活动时，用电磁线圈进行的非侵入性脑组织刺激与植入电极相比，具有几个不可替代的优势。我们审查了利用时变磁场治疗癫痫的临床病例以及与此实践相关的安全性问题。已经开发了动物模型以促进对癫痫活动的磁性控制基础的细胞/分子机制的理解。这些机制包括（但不限于）（1）磁场直接引起的膜极化，（2）离子通道失活引起的去极化阻滞，（3）突触传递的改变以及（4）中断肾小球相互作用和蜂窝同步。通过改进磁学设计，优化刺激方案以及评估长期安全性，可以改善该技术的临床翻译。专注于磁刺激机制的细胞和分子研究对促进这种翻译具有重要价值。

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