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A window into cortical development through the lens of RNA dynamics

机译：通过RNA动力学了解皮层发育的窗口

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Therapeutic implication of pharmacological evidences of excitatory dysregulation in animal models of ASD Structural plasticity of neural stem cells in mammalian brain development Neural stem cells called radial glia maintain epithelial struc- ture during cortical development. The prevailing view claims that during the proliferative stage in early development, symmetric divisions of radial glia require tight regulation of spindle orien- tation, the perturbation of which causes precocious neurogenesis and apoptosis. By contrast, in the subsequent neurogenesis, oblique spindle orientation induces the translocation of radial glia by loss of the apical endfoot to form outer radial glia, a hallmark of gyren- cephalic development. Here, we show a high regenerative ability of proliferative radial glia, which confer epithelial robustness against spindle misorientation, despite the conventional view. Regenera- ting endfeet bear ectopic adherens junctions at their leading edge. This ability declines during neurogenesis and allows the formation of outer radial glia. Our study reveals thus a temporally chang- ing cryptic property, which initially ensures symmetric divisions of radial glia and subsequently provides a basis for brain size expan- sion in mammals.
机译：ASD动物模型中兴奋性调节异常的药理学证据的治疗意义哺乳动物脑发育中神经干细胞的结构可塑性称为放射状胶质的神经干细胞在皮质发育过程中维持上皮结构。普遍的观点认为，在早期发育的增生阶段，radial神经胶质的对称分裂需要严格调节纺锤体的方向，其扰动会导致早熟的神经发生和凋亡。相反，在随后的神经发生中，倾斜的纺锤体定向会通过失去根尖端脚形成外of神经胶质而引起g神经胶质的移位，这是脑脑发育的标志。在这里，我们显示了增殖的放射状神经胶质细胞的高再生能力，尽管具有传统观点，但它们赋予了抗纺锤体定向不良的上皮坚固性。再生末梢在其前缘处具有异位粘附连接。这种能力在神经发生过程中下降，并允许形成放射状神经胶质。因此，我们的研究揭示了一种随时间变化的隐秘特性，该特性最初可确保radial神经胶质的对称分裂，随后为哺乳动物脑尺寸的扩展提供基础。

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