Mutation screening in Chinese patients with familial Alzheimer's disease by whole-exome sequencing

Qing-Qing Tao; Bin Jiang; Zhi-Ying Wu

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Mutation screening in Chinese patients with familial Alzheimer's disease by whole-exome sequencing

机译：通过全外显子测序对中国家族性阿尔茨海默氏病患者进行突变筛选

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Neurogenesis in adult hippocampus is associated with a hip- pocampal function of learning and memory and mood regulation, and is highly susceptible to psychological stress. Therefore, sup- pression of adult hippocampal neurogenesis is intimately involved in stress-induced psychological disorders, such as anxiety, depres- sion, post-traumatic stress disorder, and panic disorder. Recently, we demonstrated that both chronic restraint stress (CRS) and cor- ticosteroid hormone (CORT) causes autophagic cell death (ACD) in adult hippocampal neural stem (HCN) cells.

机译：成年海马的神经发生与学习，记忆和情绪调节的海马功能有关，并且高度易受心理压力的影响。因此，抑制成年海马神经发生与压力引起的心理疾病密切相关，例如焦虑，沮丧，创伤后应激障碍和恐慌症。最近，我们证明了慢性束缚应激（CRS）和皮质类固醇激素（CORT）均可引起成年海马神经干（HCN）细胞自噬细胞死亡（ACD）。

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《IBRO Reports》 |2019年第1期|共1页
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Qing-Qing Tao; Bin Jiang; Zhi-Ying Wu;
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中图分类神经病学与精神病学;
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1. Mutation screening in Chinese patients with familial Alzheimer's disease by whole-exome sequencing [J] . Jiang Bin, Zhou Jiong, Li Hong-Lei, Neurobiology of Aging: Experimental and Clinical Research . 2019,第期

机译：全外膜测序，中国家族阿尔茨海默病患者的突变筛选
2. Whole-exome sequencing associates novel CSMD1 gene mutations with familial Parkinson disease [J] . Javier Ruiz-Martínez, Luis J. Azcona, Alberto Bergareche, Neurology: Genetics . 2017,第5期

机译：全外显子测序将新型CSMD1基因突变与家族性帕金森病相关联
3. Whole-exome sequencing identifies a novel mutation (R367G) in SCN5A to be associated with familial cardiac conduction disease [J] . Yu Rong, Fan Xue-Feng, Chen Chan, Molecular medicine reports . 2017,第1aPta1期

机译：全末端测序识别SCN5A中的新突变（R367G）与家族性心脏传导疾病相关
4. COX-2 expression in brains of patients with familial Alzheimer's disease [C] . Shigeru Nogawa, Masaki Takao, Shigeaki Suzuki, International Symposium on Molecular Mechanism and Epochal Therapeutics for Ischemic Stroke and Dementia . 2003

机译：家族阿尔茨海默病患者患者的COX-2表达
5. The involvement of hereditary hemochromatosis mutations (C282Y and H63D) in familial Alzheimer disease and Parkinson disease and their purported origins through epidemic pathogenic selection [D] . Moalem, Sharon. 2003

机译：遗传性血细胞化突变（C282Y和H63D）在家族性阿尔茨海默病和帕金森病中的涉及及其通过流行病致病选择所称的起源
6. Analysis of a Chinese Pedigree With Familial Chylomicronemia Syndrome Reveals Two Novel LPL Mutations by Whole-Exome Sequencing [O] . Ying Liu, Zhangzhang Lan, Fang Zhao, 2020

机译：通过家族性乳糜瘤症综合征的中国血统分析揭示了两种新的LPL突变通过全外膜测序
7. Screening of dementia genes by whole-exome sequencing in early-onset Alzheimer disease: input and lessons [O] . Nicolas, Gaël, Wallon, David, Charbonnier, Camille, 2016

机译：通过全基因组测序筛选早发性阿尔茨海默病痴呆症基因：投入和教训

Mutation screening in Chinese patients with familial Alzheimer's disease by whole-exome sequencing

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