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首页> 外文期刊>IBRO Reports >IQSEC3 maintains hippocampal network activity by interacting with gephyrin and ARF6
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IQSEC3 maintains hippocampal network activity by interacting with gephyrin and ARF6

机译：IQSEC3通过与gephyrin和ARF6相互作用维持海马网络活动

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Iqsec3 KO (Iqsec3-cKO) mice, and performed a battery of behavioral analyses to reveal a specific anti-depressive- like behaviors, as analyzed by both forced swim test and tail suspension test without no abnormalities in the other behav- ioral analyses, including open-field test. These data suggest that IQSEC3 deficiency might mimic the manic facet of human patients with bipolar disorder, exhibiting increased goal-directed behav- ior specifically. To elucidate the in-depth pathological mechanism underlying manic-like behavior of Iqsec3-cKO mice, neuronal activ- ity patterns were monitored by c-FOS immunoreactivity as a surrogate for active neurons, and analyzed to determine the key brain areas that exhibit differential neuronal activities by compar- ative experiments using wild-type mice. Currently, chemogenetic and pharmacological approaches are being employed to further dissect relevant neural circuits that are abnormally altered in Iqsec3-cKO mice.
机译：Iqsec3 KO（Iqsec3-cKO）小鼠，并进行了一系列行为分析，以揭示特定的抗抑郁样行为，如通过强迫游泳试验和尾部悬吊试验所分析，在其他行为分析中均未发现异常，包括野外测试。这些数据表明，IQSEC3缺乏症可能模仿患有躁郁症的人类患者的躁狂面，表现出特定的目标定向行为。为了阐明Iqsec3-cKO小鼠躁狂样行为的深层病理机制，通过c-FOS免疫反应性监测了神经元的活动模式，以作为活动神经元的替代品，并进行分析以确定表现出差异性神经元的关键脑区域。通过使用野生型小鼠进行的对比实验来确定其活性。当前，化学和药理学方法被用于进一步解剖在Iqsec3-cKO小鼠中异常改变的相关神经回路。

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