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首页> 外文期刊>IBRO Reports >ErbB3 binding protein 1 (EBP1) is an essential regulator for embryonic development, controlling SUV39H1/DNMT1 gene-silencing unit
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ErbB3 binding protein 1 (EBP1) is an essential regulator for embryonic development, controlling SUV39H1/DNMT1 gene-silencing unit

机译：ErbB3结合蛋白1（EBP1）是胚胎发育的必需调节剂，它控制SUV39H1 / DNMT1基因沉默单元

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The identification of ubiquitin proteasome system in the developmental disease as Fragile X syndrome Most proteins undergo posttranslational modification such as acetylation methylation, phosphorylation, biotinylation, and ubiq- uitination. It is essential to regulate several cellular processes, coordinate the intracellular localization, and control the degrada- tion and so on. Ubiquitinated proteins are targeted by either 26S proteasome or deubiquitinating enzymes (DUBs) in the ubiquitin proteasome system (UPS). Balancing of UPS in protein degradation and expression is important to maintain cell homeostasis and its alteration leads to diverse diseases such as cancer, auto-immune response and neurodegenerative diseases, proteosome and lyso- some are major proteolytic machineries responsible for protein degradation. Recently, several studies showed that the roles of UPS in the normal or abnormal nervous system as brain diseases. Fragile X syndrome (FXS) is a brain disease by depletion of fragile X mental retardation protein (FMRP) and cause autism and intellectual dis- ability. Although various researches have been shown that FMRP is.
机译：在发育性疾病中将泛素蛋白酶体系统鉴定为脆性X综合征大多数蛋白质都经过翻译后修饰，例如乙酰化甲基化，磷酸化，生物素化和泛素化。调节多个细胞过程，协调细胞内定位并控制降解等至关重要。泛素化蛋白质被泛素蛋白酶体系统（UPS）中的26S蛋白酶体或去泛素化酶（DUBs）靶向。 UPS在蛋白质降解和表达中的平衡对于维持细胞稳态非常重要，其改变会导致多种疾病，例如癌症，自身免疫反应和神经退行性疾病，蛋白体和溶酶体-一些是蛋白质降解的主要蛋白水解机制。最近，一些研究表明，UPS在正常或异常神经系统中的作用是脑部疾病。脆性X综合征（FXS）是一种通过消耗脆性X智力低下蛋白（FMRP）引起的脑部疾病，会导致自闭症和智力障碍。尽管已经有各种研究表明FMRP是。

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