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首页> 外文期刊>IBRO Reports >Precise positioning of neural progenitors is essential for neocortical development
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Precise positioning of neural progenitors is essential for neocortical development

机译：神经祖细胞的精确定位对于新皮层发育至关重要

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Long-term effects of prenatal stress on chloride transporters and GABA, receptor subunits in the prefrontal cortex of periadolescent rats Early life adversities cause remarkable effects on the fetal brain development. Prenatal stress has been extensively studied about long-term negative impact on the cellular and molecular function of the offspring brain. GABAergic signaling, which is known to play an important role in excitatory/inhibitory (E/I) balance of neural cir- cuitry, greatly develop its basis during prenatal period, can be much affected by maternal stress. Chloride transporters, K*-Cl~ cotrans- porter (KCC2) and Na*-K*-Cl~ cotransporter (NKCC1), and GABA, receptor subunits expressions are all critical to the maturation of GABA neurotransmission. The upregulation of KCC2 and downregu- lation of NKCC1 produce typical GABA hyperpolarization when the central nervous system is developing to be mature. In this study, the exposure of pregnant rats to restraint stress in the last week of gestation was the model. The prefrontal cortex (PFC) of periadoles- cent rat offspring from prenatally stressed (PS) group and control group were collected at 40 days of postnatal age. We found higher NKCC1/KCC2 ratio in the PFC of PS rats and decreased KCC2 level in this group. GABA, receptor a1 subunit level was also reduced in PS group but ?5 subunit level showed a non-significant differ- ence. Altogether, these results suggested that altered maturation of GABA neurotransmission due to prenatal stress may underlie cognitive dysfunction in the offspring of stressed mothers. Alter- ations occurred during periadolescence may also predict the onset of neuropsychiatric symptoms in adulthood.
机译：产前应激对青春期大鼠前额叶皮层中氯化物转运蛋白和GABA和受体亚单位的长期影响早期的生活逆境对胎儿脑部发育产生显着影响。产前压力已被广泛研究，关于对后代大脑的细胞和分子功能的长期负面影响。已知在神经回路的兴奋性/抑制性（E / I）平衡中起重要作用的GABA能信号，在产前期会大大发展其基础，但受母体压力的影响很大。氯化物转运蛋白，K * -Cl〜共转运蛋白（KCC2）和Na * -K * -Cl〜转运蛋白（NKCC1）和GABA，受体亚基的表达对于GABA神经传递的成熟至关重要。当中枢神经系统发育成熟时，KCC2的上调和NKCC1的下调会产生典型的GABA超极化。在这项研究中，妊娠大鼠在妊娠的最后一周暴露于束缚压力中，是模型。在出生后40天收集来自产前应激（PS）组和对照组的腹膜周围大鼠后代的前额叶皮层（PFC）。我们发现PS大鼠的PFC中的NKCC1 / KCC2比值更高，而该组中的KCC2水平降低。 PS组的GABA，受体a1亚基水平也降低了，但是？5亚基水平没有显着差异。总之，这些结果表明，由于产前压力而导致的GABA神经传递的成熟改变可能是压力母亲的后代认知功能障碍的基础。在青春期期间发生的变化也可能预示了成年后神经精神症状的发作。

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