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首页> 外文期刊>Immunity Ageing >Long-term maintenance of diphtheria-specific antibodies after booster vaccination is hampered by latent infection with Cytomegalovirus
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Long-term maintenance of diphtheria-specific antibodies after booster vaccination is hampered by latent infection with Cytomegalovirus

机译：巨细胞病毒潜伏感染阻碍了加强疫苗接种后白喉特异性抗体的长期维持

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AbstractMany currently used vaccines are less immunogenic in the elderly compared to young adults. The impact of latent infection with Cytomegalovirus (CMV) on vaccine-induced antibody responses has been discussed controversially. We have demonstrated that recall responses to diphtheria vaccination are frequently insufficient in elderly persons and that antibody concentrations decline substantially within 5?years. In the current study we show that within a cohort of healthy elderly ( n =?87; median age 71?years, range 66–92) antibody responses to a booster vaccination against diphtheria do not differ between CMV-negative and CMV-positive individuals 4?weeks after vaccination.. However, the goal of diphtheria-vaccination is long-term protection and this is achieved by circulating anti-toxin antibodies. Diphtheria-specific antibody concentrations decline faster in CMV-positive compared to CMV-negative older adults leading to an increased proportion of persons without protective antibody concentrations 5?years after booster vaccination and endangering long-term protection. This finding could be relevant for vaccination schedules.
机译：摘要与年轻人相比，许多目前使用的疫苗在老年人中的免疫原性较低。有争议地讨论了巨细胞病毒（CMV）潜在感染对疫苗诱导的抗体反应的影响。我们已经证明，老年人对白喉疫苗的召回反应常常不足，并且抗体浓度在5年内会大大下降。在当前的研究中，我们显示在一群健康的老年人（n =？87;中位年龄71？岁，范围66-92）中，针对白喉加强免疫的抗体反应在CMV阴性和CMV阳性个体之间没有差异疫苗接种后4周。然而，白喉疫苗的目标是长期保护，这是通过循环抗毒素抗体来实现的。与CMV阴性的成年人相比，CMV阳性的白喉特异性抗体浓度下降得更快，导致加强疫苗接种5年后无保护性抗体浓度的人群比例增加，并危及长期保护。这一发现可能与疫苗接种时间表有关。

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