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Low expression of CD39 and CD73 genes in centenarians compared with octogenarians

机译：与八十岁老人相比，CD39和CD73基因在百岁老人中的低表达

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Ageing involves a progressive decline of the body’s regulatory systems including immune system. Adenosine regulates immune function by interaction with its receptors, mainly adenosine A2A receptor, present on the surface of immune cells. Furthermore, cellular response to this nucleoside is highly dependent on its extracellular concentration that is regulated by ecto-enzymes such as CD39 and CD73. Therefore, the aim of this study was to investigate the effect of age on adenosine A2A receptor, CD39 and CD73 gene expression. Changes in mRNA were measured by quantitative PCR from peripheral blood of young, middle-aged and older adults as well as centenarians. Centenarians showed a prominent decrease of CD39 and CD73 mRNA in comparison with older adults. Regarding to adenosine A2A receptor, we detected two subgroups of centenarians with high and low level of transcript. Additionally, adenosine A2A receptor mRNA level of centenarians, did not correlate with their cognitive impairment. In summary, our pilot study suggests that unlike of adenosine A2A receptor, the level of CD39 as well as CD73 mRNA could be a hallmark of successful human ageing.
机译：衰老涉及人体调节系统（包括免疫系统）的逐步下降。腺苷通过与其免疫细胞表面上的受体（主要是腺苷A2A受体）相互作用来调节免疫功能。此外，细胞对这种核苷的反应高度依赖于其胞外浓度，胞外浓度由诸如CD39和CD73的胞外酶调节。因此，本研究的目的是研究年龄对腺苷A2A受体，CD39和CD73基因表达的影响。通过定量PCR测定了年轻人，中年和老年人以及百岁老人外周血中mRNA的变化。与老年人相比，百岁老人显示出CD39和CD73 mRNA的显着下降。关于腺苷A2A受体，我们检测到两个百岁老人亚组，其转录水平高低不一。此外，百岁老人的腺苷A2A受体mRNA水平与他们的认知障碍无关。总而言之，我们的初步研究表明，与腺苷A2A受体不同，CD39和CD73 mRNA的水平可能是人类成功衰老的标志。

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