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首页> 外文期刊>Indian Journal of Critical Care Medicine >Extracorporeal treatment with high-volume continuous venovenous hemodiafiltration and charcoal-based sorbent hemoperfusion for severe metformin-associated lactic acidosis
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Extracorporeal treatment with high-volume continuous venovenous hemodiafiltration and charcoal-based sorbent hemoperfusion for severe metformin-associated lactic acidosis

机译：大剂量连续静脉血液透析滤过和木炭为基础的吸附性血液灌流治疗严重二甲双胍相关的乳酸性酸中毒的体外治疗

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摘要

We present a case of a 49-year-old female with an alleged history of ingestion of approximately 100 tablets of metformin (850 mg each). Investigations revealed severe lactic acidosis with lactate levels of 13.5 mmol/L and pH of 7.17. This indicates severe toxicity and is associated with a high mortality. Charcoal-based sorbent hemoperfusion was done as a desperate effort, as patient continued to deteriorate despite supportive care and high-volume continuous venovenous hemodiafiltration. The patient survived despite metformin-associated lactic acidosis related to severe metformin toxicity.
机译：我们介绍了一例49岁的女性，据称其摄入了大约100片二甲双胍（每次850毫克）。调查显示严重的乳酸性酸中毒，乳酸水平为13.5 mmol / L，pH为7.17。这表明严重的毒性并伴有高死亡率。由于缺乏支持治疗和大量连续静脉血液透析滤过，患者仍在恶化，因此以木炭为基础的吸附剂血液灌流是一项拼命的工作。尽管与二甲双胍相关的乳酸酸中毒与严重的二甲双胍毒性有关，但该患者仍然存活。

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