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首页> 外文期刊>Indian Journal of Critical Care Medicine >Clinical profile, intensive care unit course, and outcome of patients admitted in intensive care unit with chikungunya
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Clinical profile, intensive care unit course, and outcome of patients admitted in intensive care unit with chikungunya

机译：基孔肯雅病的临床概况，重症监护病房病程以及重症监护病房的入院患者结局

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Objective: Chikungunya is generally a mild disease, rarely requiring Intensive Care Unit (ICU) admission. However, certain populations may develop organ dysfunction necessitating ICU admission. The purpose of the study was to assess the clinical profile and course of chikungunya patients admitted to the ICU, and to ascertain factors linked with poor outcome. Methods: All patients with chikungunya admitted to ICU were included in the study. Admission Acute Physiology and Chronic Health Evaluation (APACHE) II score and sequential organ failure assessment (SOFA) score were calculated. Primary outcome measured was 28-day mortality and secondary outcomes measured were length of hospital and ICU stay and the need for vasopressor support, renal replacement therapy (RRT), and mechanical ventilation (MV). Logistic regression analysis was performed to identify factors predicting mortality. Results: The most common complaints were fever (96.67%) and altered sensorium (56.67%). Mean admission APACHE II and SOFA scores were 17.28 ± 7.9 and 7.15 ± 4.2, respectively. Fifty-one patients had underlying comorbidities. Vasopressors were required by 46.76%; RRT by 26.67%, and MV by 58.33%, respectively. The 28-day mortality was 36.67%. High APACHE II score (odds ratio: 1.535; 95% confidence interval: 1.053–2.237; P = 0.026) and need for dialysis (odds ratio: 833.221; 95% confidence interval: 1.853–374,664.825; P = 0.031) could independently predict mortality. Conclusions: Patients with chikungunya fever may require ICU admission for organ failure. They are generally elderly patients with underlying comorbidities. Despite aggressive resuscitation and organ support, these patients are at high risk of death. Admission APACHE II score and need for dialysis may predict patients at higher risk of death.
机译：目的：基孔肯雅病通常为轻度疾病，很少需要重症监护病房（ICU）入院。但是，某些人群可能会出现器官功能障碍，因此需要入住ICU。该研究的目的是评估接受ICU治疗的基孔肯雅病患者的临床特征和病程，并确定与不良预后相关的因素。方法：所有纳入ICU的基孔肯雅热患者均纳入研究。计算入院急性生理和慢性健康评估（APACHE）II分数和连续器官衰竭评估（SOFA）分数。测得的主要结局为28天死亡率，测得的次要结局为住院时间和ICU住院时间，以及是否需要使用血管加压药，肾替代疗法（RRT）和机械通气（MV）。进行逻辑回归分析以鉴定预测死亡率的因素。结果：最常见的主诉是发烧（96.67％）和感觉改变（56.67％）。平均入学APACHE II和SOFA评分分别为17.28±7.9和7.15±4.2。 51名患者有潜在的合并症。血管加压药的需求量为46.76％; RRT分别为26.67％和MV为58.33％。 28天死亡率为36.67％。 APACHE II评分高（赔率：1.535; 95％置信区间：1.053–2.237; P = 0.026）和需要透析（赔率：833.221; 95％可信区间：1.853–374,664.825; P = 0.031）可以独立预测死亡率。结论：基孔肯雅热患者可能因器官衰竭而需要ICU入院。他们通常是具有潜在合并症的老年患者。尽管进行了积极的复苏和器官支持，这些患者仍有很高的死亡风险。入院APACHE II评分和透析需求可能预示患者死亡风险更高。

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