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首页> 外文期刊>Indian Journal of Endocrinology and Metabolism >Subclinical hypothyroidism and cardiac risk: Lessons from a South Indian population study
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Subclinical hypothyroidism and cardiac risk: Lessons from a South Indian population study

机译：亚临床甲状腺功能减退症和心脏风险：来自南印度人口研究的教训

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Introduction: The benefits of treating subclinical hypothyroidism are currently under debate, prevention of adverse cardiac events purporting to be one of the main benefits. The effect of subclinical hypothyroidism on the cardiovascular health of the Indian sub-population is largely unknown. This study was designed to examine these effects and to help guide treatment of this disorder. Methods: A cross-sectional adult population survey was carried out in urban coastal area of central Kerala. 986 volunteers underwent complete biochemical and physical examinations, 110 were found to have subclinical hypothyroidism (8.9%). The ten-year risk of an adverse cardiac event, was calculated using the Framingham score algorithm. Eligible subclinical hypothyroid subjects (N = 110) and a randomly selected, age and gender matched control group (N = 220) were compared. Results: This population was found to have high baseline levels of diabetes 19.5%, hypercholesterolemia 57.2% and systolic hypertension 24.6%. No association was found between subclinical hypothyroid status or rising TSH and Framingham 10-year risk. While no difference between groups was noted with respect to lipid profile, a rising TSH was found to be significantly correlated with mild worsening of the lipid profile. A significant positive correlation was found between skinfold thickness and TSH. Conclusions: Subclinical hypothyroidism is not a contributing factor to elevated Framingham risk in this population, and while a mild effect was observed on the lipid profile, its effect is unlikely to be clinically relevant. We hypothesize that in this population a genetic component may be responsible for the uniquely high rates of metabolic syndrome and other endocrine diseases.
机译：简介：治疗亚临床甲状腺功能减退症的益处目前仍在争论中，预防不良心脏事件据称是主要益处之一。亚临床甲状腺功能减退症对印度亚人群心血管健康的影响在很大程度上尚不清楚。本研究旨在检查这些影响并帮助指导该疾病的治疗。方法：在喀拉拉邦中部城市沿海地区进行横断面成年人口调查。 986名志愿者接受了全面的生化和身体检查，其中110名患有亚临床甲状腺功能减退症（8.9％）。使用Framingham评分算法计算发生心脏不良事件的十年风险。比较合格的亚临床甲状腺功能减退受试者（N = 110）和年龄，性别匹配的对照组（N = 220）。结果：发现该人群的糖尿病基线水平高，为19.5％，高胆固醇血症为57.2％，收缩期高血压为24.6％。在亚临床甲状腺功能减退状态或TSH升高与Framingham 10年风险之间未发现关联。虽然在脂谱方面没有观察到两组之间的差异，但是发现升高的TSH与脂谱的轻度恶化显着相关。发现皮褶厚度与TSH之间存在显着的正相关。结论：亚临床甲状腺功能减退症不是导致该人群Framingham风险升高的因素，尽管在血脂方面观察到温和的作用，但其作用不太可能与临床相关。我们假设在这一人群中，遗传因素可能是导致代谢综合征和其他内分泌疾病的高发生率的原因。

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