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首页> 外文期刊>Indian Journal of Endocrinology and Metabolism >Neck circumference to height ratio is a reliable predictor of liver stiffness and nonalcoholic fatty liver disease in prediabetes
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Neck circumference to height ratio is a reliable predictor of liver stiffness and nonalcoholic fatty liver disease in prediabetes

机译：颈围与身高之比是糖尿病前期肝硬度和非酒精性脂肪肝疾病的可靠预测指标

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Background and Objectives: Nonalcoholic fatty liver disease (NAFLD) and dysglycemia are public health challenges. There is urgent need for anthropometric surrogates for NAFLD screening. This study evaluated role of neck circumference (NC) and neck-height ratio (NHtR) as predictors of liver stiffness measure (LSM) in individuals with prediabetes (IPD). Methods: In a cross-sectional study, 188 IPD from 1130 screened individuals underwent anthropometry, ultrasonography, Fibroscan? for LSM, dyslipidemia, insulin resistance (IR), and fetuin-A assessment. Results: Hypertension, hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-C), metabolic syndrome (MetS), NAFLD, and significant liver stiffness (SLS) (LSM >8.5kPa) were observed in 53.7%, 31.4%, 71.3%, 73.9%, 24.5%, and 11.2% prediabetes individuals, respectively. Prediabetes with NAFLD had significantly higher body mass index (BMI), NC, NHtR, glycated hemoglobin, triglycerides, fatty liver index (FLI), and LSM. Prediabetes in highest NHtR quartile had significantly higher BMI, hypertension, MetS, fasting glucose, glycated hemoglobin, homeostatic model assessment-IR, NAFLD, LSM, SLS, and lower HDL-C. Stepwise forward linear regression revealed that NHtR, FLI, and LDL-C were best predictors of LSM, at baseline (Model-1), after adjusting for age and sex (Model-2), and adjusting model-2 plus systolic and diastolic blood pressure (Model-3). NHtR and NC (in females) and NHtR and BMI (in males) had largest area under the curves for predicting LSM, NAFLD, and MetS. NHtR ≥21.54 cm/m (sensitivity: 90%; specificity: 52.5%; females) and ≥21.62 cm/m (sensitivity: 80%; specificity: 49.4%; males) was best predictor of SLS. Interpretation and Conclusion: NHtR is a reliable tool for community screening of NAFLD and liver stiffness in prediabetes.
机译：背景与目的：非酒精性脂肪肝（NAFLD）和血糖异常是公共卫生方面的挑战。迫切需要用于NAFLD筛查的人体测量替代物。这项研究评估了前围（IPD）患者的颈围（NC）和颈高比（NHtR）作为肝硬度测量（LSM）的预测指标的作用。方法：在一项横断面研究中，对来自1130名筛查个体的188个IPD进行了人体测量，超声检查，Fibroscan ？进行LSM，血脂异常，胰岛素抵抗（IR）和胎球蛋白A评估。结果：观察到高血压，高甘油三酯血症，低密度脂蛋白胆固醇（HDL-C），代谢综合征（MetS），NAFLD和显着肝硬度（SLS）（LSM> 8.5kPa）分别为53.7％，31.4％，71.3％分别为73.9％，24.5％和11.2％的糖尿病前个体。患有NAFLD的糖尿病前期患者的体重指数（BMI），NC，NHtR，糖化血红蛋白，甘油三酸酯，脂肪肝指数（FLI）和LSM明显更高。 NHtR最高四分位数的前驱糖尿病具有显着较高的BMI，高血压，MetS，空腹血糖，糖化血红蛋白，稳态模型评估IR，NAFLD，LSM，SLS和较低的HDL-C。逐步向前线性回归显示，在校正年龄和性别（模型2）并调整模型2加上收缩期和舒张期血后，在基线时（模型1），NHtR，FLI和LDL-C是LSM的最佳预测指标压力（型号3）。在预测LSM，NAFLD和MetS的曲线下，NHtR和NC（女性）和NHtR和BMI（男性）的面积最大。 NHtR≥21.54cm / m（敏感性：90％;特异性：52.5％;女性）和≥21.62cm / m（敏感性：80％;特异性：49.4％;男性）是SLS的最佳预测指标。解释和结论：NHtR是用于社区筛查糖尿病前期NAFLD和肝硬度的可靠工具。

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