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首页> 外文期刊>Indian Journal of Endocrinology and Metabolism >Prevalence of hypothyroidism in adults: An epidemiological study in eight cities of India
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Prevalence of hypothyroidism in adults: An epidemiological study in eight cities of India

机译：成人甲状腺功能减退症的流行：印度八个城市的流行病学研究

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Background:Hypothyroidism is believed to be a common health issue in India, as it is worldwide. However, there is a paucity of data on the prevalence of hypothyroidism in adult population of India.Materials and Methods:A cross-sectional, multi-centre, epidemiological study was conducted in eight major cities (Bangalore, Chennai, Delhi, Goa, Mumbai, Hyderabad, Ahmedabad and Kolkata) of India to study the prevalence of hypothyroidism among adult population. Thyroid abnormalities were diagnosed on the basis of laboratory results (serum FT3, FT4 and Thyroid Stimulating Hormone [TSH]). Patients with history of hypothyroidism and receiving levothyroxine therapy or those with serum free T4 5.50 μU/ml, were categorized as hypothyroid. The prevalence of self reported and undetected hypothyroidism, and anti-thyroid peroxidase (anti-TPO) antibody positivity was assessed.Results:A total of 5376 adult male or non-pregnant female participants ≥18 years of age were enrolled, of which 5360 (mean age: 46 ± 14.68 years; 53.70% females) were evaluated. The overall prevalence of hypothyroidism was 10.95% (n = 587, 95% CI, 10.11-11.78) of which 7.48% (n = 401) patients self reported the condition, whereas 3.47% (n = 186) were previously undetected. Inland cities showed a higher prevalence of hypothyroidism as compared to coastal cities. A significantly higher (P 5.50 μIU/ml). Anti – TPO antibodies suggesting autoimmunity were detected in 21.85% (n = 1171) patients.Conclusion:The prevalence of hypothyroidism was high, affecting approximately one in 10 adults in the study population. Female gender and older age were found to have significant association with hypothyroidism. Subclinical hypothyroidism and anti-TPO antibody positivity were the other common observations.
机译：背景：甲状腺功能减退症被认为是印度普遍存在的健康问题，在世界范围内也是如此。然而，印度成年人口甲状腺功能低下流行的数据很少。材料与方法：在八个主要城市（班加罗尔，金奈，德里，果阿，孟买）进行了横断面，多中心，流行病学研究，印度海得拉巴，艾哈迈达巴德和加尔各答）研究成年人口甲减的患病率。根据实验室检查结果（血清FT3，FT4和甲状腺刺激激素[TSH]）诊断甲状腺异常。有甲状腺功能减退病史并接受左甲状腺素治疗的患者或无血清T4 5.50μU/ ml的患者归为甲状腺功能减退。评估了自我报告和未发现的甲状腺功能减退症的患病率以及抗甲状腺过氧化物酶（anti-TPO）抗体的阳性率。结果：总共招募了5376名18岁以上的成年男性或未怀孕女性参与者，其中5360（平均年龄：46±14.68岁;女性为53.70％。甲状腺功能减退症的总患病率为10.95％（n = 587，95％CI，10.11-11.78），其中7.48％（n = 401）患者自行报告该病，而先前未发现过3.47％（n = 186）。与沿海城市相比，内陆城市甲状腺功能减退的患病率更高。明显更高（P 5.50μIU/ ml）。在21.85％（n = 1171）的患者中检测到提示自身免疫的抗TPO抗体。结论：甲状腺功能减退症的患病率很高，影响了研究人群中十分之一的成年人。发现女性和年龄较大与甲状腺功能减退有显着相关性。亚临床甲状腺功能减退和抗TPO抗体阳性是其他常见观察结果。

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