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首页> 外文期刊>Indian Journal of Endocrinology and Metabolism >A study on metabolic variables and its association with high sensitive C-reactive protein in obese children and adolescents
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A study on metabolic variables and its association with high sensitive C-reactive protein in obese children and adolescents

机译：肥胖儿童和青少年代谢变量及其与高敏C反应蛋白的相关性研究

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Obesity in children and adolescents predispose to the development of obesity in adulthood and subsequent cardiovascular disease. High-sensitivity C-reactive protein (hsCRP) is a marker of low grade inflammatory state, which characterizes an atherosclerotic process. The aim of this study was to assess the metabolic abnormalities and its association with hsCRP in obese children and adolescents. A total of 62 obese children and adolescents and 24 healthy children and adolescents with a normal weight were recruited. In all subjects, anthropometric and biochemical parameters were measured. Body mass index (BMI) and blood pressure were significantly higher in the obese children and adolescents than the control. Obese children had significantly higher hsCRP levels (P < 0.001), total cholesterol, triglyceride, low-density lipoprotein-cholesterol (LDL-C) and lower high-density lipoprotein-cholesterol than the control group. Furthermore, homeostatic model assessment-insulin resistance (HOMA-IR) was significantly higher in obese children compared with the normal weight children. Furthermore, hsCRP showed a positive correlation with BMI (r = 0.357; P = 0.028), total cholesterol (r = 0.367; P = 0.008) and LDL-C (r = 0.356; P = 0.01), insulin (r = 0.311; P = 0.026) and not with HOMA-IR (r = 0.244; P = 0.084)). In conclusion, obese children and adolescents have significantly increased hsCRP compared with a normal weight group. Early intervention and prevention of obesity in children and adolescents decreases cardiovascular disease in later life.Keywords: Cardiovascular risk, high sensitive C-reactive protein, obesity
机译：儿童和青少年的肥胖症容易导致肥胖症在成年后发展，并随后发生心血管疾病。高敏C反应蛋白（hsCRP）是低度炎症状态的标志物，是动脉粥样硬化过程的特征。这项研究的目的是评估肥胖儿童和青少年的代谢异常及其与hsCRP的关系。总共招募了62名体重正常的肥胖儿童和青少年，以及24名健康的儿童和青少年。在所有受试者中，均测量了人体测量学和生化参数。肥胖儿童和青少年的体重指数（BMI）和血压显着高于对照组。肥胖儿童的hsCRP水平明显高于对照组（P <0.001），总胆固醇，甘油三酸酯，低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇较低。此外，与正常体重的儿童相比，肥胖儿童的稳态模型评估胰岛素抵抗（HOMA-IR）显着更高。此外，hsCRP与BMI（r = 0.357; P = 0.028），总胆固醇（r = 0.367; P = 0.008）和LDL-C（r = 0.356; P = 0.01），胰岛素（r = 0.311; P = 0.026），而不是使用HOMA-IR（r = 0.244; P = 0.084））。总之，与正常体重组相比，肥胖儿童和青少年的hsCRP显着增加。儿童和青少年的肥胖症的早期干预和预防在以后的生活中减少心血管疾病。关键字：心血管疾病的风险，高敏C反应蛋白，肥胖

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