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首页> 外文期刊>Indian Journal of Medical Microbiology >Seroprevalence of Toxoplasmosis at a Tertiary Care Centre in North India from 2004 to 2014
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Seroprevalence of Toxoplasmosis at a Tertiary Care Centre in North India from 2004 to 2014

机译：2004年至2014年在印度北部的一家三级医疗中心检测弓形虫的血清阳性率

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Purpose: This study was carried out to determine the seroprevalence of anti-Toxoplasma gondii antibodies in different groups of patients at a tertiary care hospital in North India. Materials and Methods: Clinical and demographic data such as age and gender of patients who had undergone testing for the presence of anti-T. gondii IgG and IgM antibodies between January 2004 and October 2014 were retrospectively analysed. Results: Amongst the 8397 serum samples, an overall seropositivity of 21% (n = 1763) and IgG and IgM seropositivity of 5.7% (n = 481) and 15.3% (n = 1282) were respectively observed. Compared to the period of 2004–2012 (median seroprevalence: 23.6%), a decline in seropositivity to 9.7% in 2013 and 8.1% in 2014 was noted. A rising seroprevalence with age and a higher seroprevalence in females versus males (29.5%, n = 1179 vs. 13.3%, n = 584) were recorded. The highest seroprevalence was observed in suspected ocular toxoplasmosis (47.2%, n = 47), followed by neurological (26.8%, n = 77), human immunodeficiency virus/acquired immunodeficiency syndrome (18.9%, n = 267), post-transplant (17.1%, n = 12) and congenital (7.2%, n = 144) toxoplasmosis. In patients screened for Toxoplasma exposure, the seropositivity was 47.8% (n = 11) in transplant screening and 44.9% (n = 781) in antenatal screening. Conclusion: Toxoplasma infection is highly prevalent in the population of North India across various clinical categories of patients. Future studies focusing on continuous monitoring of seroprevalence trends and elucidation of the risk factors associated with seropositivity in more defined groups of patients are needed.
机译：目的：本研究旨在确定印度北部一家三级护理医院不同人群患者中的弓形虫抗弓形虫抗体的血清阳性率。材料和方法：临床和人口统计数据，例如接受过抗T检测的患者的年龄和性别。回顾性分析2004年1月至2014年10月之间的刚地IgG和IgM抗体。结果：在8397份血清样本中，总体血清阳性率为21％（n = 1763），IgG和IgM血清阳性率为5.7％（n = 481）和15.3％（n = 1282）。与2004-2012年期间（血清阳性率中位数：23.6％）相比，血清阳性率下降到2013年的9.7％和2014年的8.1％。记录的血清阳性率随年龄增长而上升，女性相对于男性的血清阳性率更高（29.5％，n = 1179对13.3％，n = 584）。在疑似眼弓形虫病中发现最高的血清阳性率（47.2％，n = 47），其次是神经系统疾病（26.8％，n = 77），人免疫缺陷病毒/后天免疫缺陷综合症（18.9％，n = 267），移植后（ 17.1％，n = 12）和先天性（7.2％，n = 144）弓形虫病。在接受弓形虫暴露筛查的患者中，移植筛查的血清阳性率为47.8％（n = 11），产前筛查的血清阳性率为44.9％（n = 781）。结论：弓形虫感染在印度北部的各个临床类别的患者中非常普遍。未来的研究需要集中监测血清阳性率趋势，并阐明在更明确的患者群体中与血清阳性相关的危险因素。

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