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首页> 外文期刊>Indian Journal of Medical Microbiology >Utility of QuantiFERON?-TB gold In-Tube test compared with tuberculin skin test in diagnosing tuberculosis in Indian children with malnutrition
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Utility of QuantiFERON?-TB gold In-Tube test compared with tuberculin skin test in diagnosing tuberculosis in Indian children with malnutrition

机译：QuantiFERON？-TB黄金管内试验与结核菌素皮肤试验相比较在印度营养不良儿童中诊断结核病的实用性

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摘要

This prospective cohort study was conducted to compare the accuracy of QuantiFERONsup?/sup-TB (QFT) Gold In-Tube test and tuberculin skin test (TST) in diagnosing tuberculosis (TB) in predominantly bacille Calmette–Guerin-vaccinated children with a high incidence of malnutrition. The sensitivity of the QFT versus the TST was 69.6% versus 52.9% for WHO-defined TB, with specificity of 86% versus 78.3%, respectively. The concordance of the TST and QFT was 79% overall (κ = 0.430), 62.5% in those with WHO-defined TB and 85.7% in those without TB. Majority of the QFT+/TST ? discordance was seen in children with TB, whereas majority of the TST+/QFT ? discordance was seen in those without TB. The TST was more likely to be negative in children with moderate-to-severe malnutrition (P = 0.003) compared to the QFT, which was more likely to be positive in younger children. The significantly better performance of the QFT in malnourished children and those at younger ages supports its use for TB diagnosis in these subpopulations.
机译：这项前瞻性队列研究旨在比较QuantiFERON ？ -TB（QFT）金管内测试和结核菌素皮肤测试（TST）在主要诊断细菌Calmette–Guerin-接种疫苗的儿童营养不良发生率很高。对于世界卫生组织定义的结核病，QFT对TST的敏感性为69.6％，而对TST的敏感性为52.9％，特异性分别为86％和78.3％。 TST和QFT的总体一致性为79％（κ= 0.430），在WHO定义的结核病患者中为62.5％，在无结核病患者中为85.7％。 QFT + / TST的大多数？在结核病儿童中发现不一致，而大多数TST + / QFT？在没有结核病的人群中发现不一致。与QFT相比，中度至重度营养不良的儿童中TST阴性的可能性更大（P = 0.003），而在较小的儿童中，TST的可能性更大。 QFT在营养不良的儿童和年龄较小的儿童中的显着好转，支持将其用于这些亚人群的结核病诊断。

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