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首页> 外文期刊>Indian Journal of Medical Microbiology >Insights to the diphtheria toxin encoding prophages amongst clinical isolates of Corynebacterium diphtheriae from India
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Insights to the diphtheria toxin encoding prophages amongst clinical isolates of Corynebacterium diphtheriae from India

机译：印度白喉棒状杆菌临床分离株中对白喉毒素编码噬菌体的见解

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摘要

Diphtheria is a dreadful disease caused by Corynebacterium diphtheriae. Lysogenised bacteriophages carrying toxin gene in C. diphtheriae can make the strain toxigenic. However, such phage disseminates the toxin genes to other strains when it undergoes lytic phase. As little is known about the phage diversity in C. diphtheriae in India, the present study was undertaken to investigate the prophages integrated into the genome of 29 clinical isolates of C. diphtheriae using whole-genome shotgun sequencing. Amongst these isolates, 27 were toxigenic, while 2 were non-toxigenic strains. Of the 27 toxigenic strains, all harbored known phages carrying toxin gene and two other phages with unknown function. However, the two non-toxin strains did not harbour any of the phages in the genome. It is imperative to devise prevention strategies that hinder the dissemination of toxin by prophages, as it may increase the complications of diphtheria post-immunisation.
机译：白喉是由白喉棒状杆菌引起的可怕疾病。在白喉衣原体中携带毒素基因的经溶菌的噬菌体可以使该菌株产生毒素。但是，这种噬菌体在经历裂解阶段时会将毒素基因传播给其他菌株。由于对印度白喉衣原体的噬菌体多样性了解甚少，因此本研究旨在使用全基因组shot弹枪测序研究整合到29种白喉衣原体临床分离株基因组中的噬菌体。在这些分离物中，有27株是产毒菌株，而2株是非产毒菌株。在这27种产毒菌株中，所有菌株均带有携带毒素基因的已知噬菌体和另外两种功能未知的噬菌体。但是，这两种非毒素菌株在基因组中没有任何噬菌体。当务之急是制定预防策略，以阻止前夜传播毒素，因为这可能会增加免疫后白喉的并发症。

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