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首页> 外文期刊>American Journal of Immunology >The Pathology of Alzheimer Disease Elicits an In Vivo Immunological Response | Science Publications
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The Pathology of Alzheimer Disease Elicits an In Vivo Immunological Response | Science Publications

机译：阿尔茨海默氏病的病理学引发体内免疫反应科学出版物

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> The mechanism(s) responsible for the loss of neurons that characterizes Alzheimer disease is incompletely understood. Nonetheless, there is considerable evidence suggestive of immune abnormalities coupled to alterations in blood-brain barrier permeability that likely play a key role in both the etiology and progression of the disease. To examine these issues further, this study was designed to examine the presence of human antibodies within hippocampal regions of both diseased and normal brains. Specifically, using antibodies directed against either human lambda (λ) or kappa (κ) subunits of human IgG, we examined the amount and localization of endogenous human antibodies within the brain. In cases of Alzheimer disease, but not in age-matched controls, we found human antibodies associated with pyramidal neurons and dystrophic neurites surrounding amyloid plaques - pathological structures that characterize the disease. Since such human immunoglobulins likely originate in the vasculature, we also examined cases of cerebral amyloid angiopathy to further explore the importance of blood-brain barrier breaches and found high levels of antibodies associated with many blood vessels as well as pyramidal neurons. Taken together, these findings strengthen the notion that alterations in blood brain barrier permeability in both Alzheimer disease and cerebral amyloid angiopathy leads to the accumulation of antibodies that then may contribute to the inflammatory cascade within the brain.
机译： >对于导致阿尔茨海默氏病的神经元丢失的机制尚不完全清楚。尽管如此，仍有大量证据表明免疫异常与血脑屏障通透性的改变有关，这可能在疾病的病因和进展中起关键作用。为了进一步检查这些问题，本研究旨在检查人类抗体在患病大脑和正常大脑海马区内的存在。具体而言，使用针对人IgG的人λ（λ）或κ（κ）亚基的抗体，我们检查了大脑中内源性人抗体的数量和定位。在阿尔茨海默氏病的病例中，但在年龄匹配的对照中则没有，我们发现与淀粉样蛋白斑周围的锥体神经元和营养不良的神经突相关的人类抗体-表征该病的病理结构。由于此类人免疫球蛋白可能起源于脉管系统，因此我们还检查了脑淀粉样血管病的病例，以进一步探索血脑屏障破坏的重要性，并发现与许多血管以及锥体神经元相关的抗体水平高。综上所述，这些发现强化了这样的观念，即阿尔茨海默氏病和脑淀粉样血管病中血脑屏障通透性的改变会导致抗体积聚，从而可能导致大脑内的炎症级联反应。

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