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首页> 外文期刊>Indian Journal of Medical Microbiology >Evaluation of the microscopic observational drug susceptibility assay for rapid and efficient diagnosis of multi-drug resistant tuberculosis
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Evaluation of the microscopic observational drug susceptibility assay for rapid and efficient diagnosis of multi-drug resistant tuberculosis

机译：显微镜观察药敏试验对多药耐药结核病快速有效诊断的评估

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Purpose: Tuberculosis (TB) is endemic in India and the burden of multi-drug-resistant tuberculosis (MDR-TB) is high. Early detection of MDR-TB is of primary importance in controlling the spread of TB. The microscopic observational drug susceptibility (MODS) assay has been described as a cost-effective and rapid method by which mycobacterial culture and the drug susceptibility test (DST) can be done at the same time. Materials and Methods: A total of 302 consecutive sputum samples that were received in an accredited mycobacteriology laboratory for conventional culture and DST were evaluated by the MODS assay. Results: In comparison with conventional culture on Lowenstein Jensen (LJ) media, the MODS assay showed a sensitivity of 94.12% and a specificity of 89.39% and its concordance with the DST by the proportion method on LJ media to isoniazid and rifampicin was 90.8% and 91.5%, respectively. The turnaround time for results by MODS was 9 days compared to 21 days by culture on LJ media and an additional 42 days for DST by the 1% proportion method. The cost of performing a single MODS assay was Rs. 250/-, compared to Rs. 950/- for culture and 1st line DST on LJ. Conclusion: MODS was found to be a sensitive and rapid alternative method for performing culture and DST to identify MDR-TB in resource poor settings.
机译：目的：结核病（TB）在印度很流行，耐多药结核病（MDR-TB）的负担很高。尽早发现耐多药结核病对于控制结核病的传播至关重要。显微镜观察药物敏感性（MODS）测定已被描述为一种经济高效的快速方法，通过该方法可同时进行分枝杆菌培养和药物敏感性试验（DST）。材料和方法：通过MODS分析评估了在经认可的分枝杆菌实验室进行常规培养和DST的总共302份连续痰标本。结果：与Lowenstein Jensen（LJ）培养基上的常规培养相比，MODS分析显示灵敏度为94.12％，特异性为89.39％，与LST培养基按比例法与异烟肼和利福平的DST一致性为90.8％。和91.5％。 MODS结果的周转时间为9天，而在LJ培养基上培养的结果为21天，而DST通过1％比例方法的结果则为42天。进行单个MODS分析的成本为Rs。 250 /-，相比卢比。 950 /-用于LJ文化和一线DST。结论：发现MODS是进行培养和DST鉴定资源贫乏地区MDR-TB的灵敏且快速的替代方法。

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