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首页> 外文期刊>Indian Journal of Nuclear Medicine >Fibrodysplasia ossificans progressiva – A rare genetic disorder and the role of Technetium-99m methylene diphosphonate bone scan
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Fibrodysplasia ossificans progressiva – A rare genetic disorder and the role of Technetium-99m methylene diphosphonate bone scan

机译：骨化性纤维增生症–一种罕见的遗传疾病和and 99m亚甲基二膦酸骨扫描的作用

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Fibrodysplasia ossificans progressiva is a rare genetic disease believed to occur in approximately 1 in 2 million people worldwide and is characterized by progressive extraosseous ossification over the course of a lifetime in an inevitable and unpredictable episodic manner, with most patients being confined to a wheelchair by the third decade of life and requiring life-long care. The extraosseous calcification involves ligaments, tendons, muscles, and connective tissue leading to severe restriction of movements. Another hallmark of this condition is abnormal great toes. The diagnosis is often made on clinical and radiological examination, but Technetium-99m methylene diphosphonate (Tc-99m MDP) bone scan is usually indicated to determine the extent of the disease. We hereby present a case series comprising of four patients suffering from this debilitating illness who underwent Tc99m MDP bone scan for initial diagnosis and localizing sites of heterotopic ossification.
机译：骨化性纤维增生是一种罕见的遗传病，据信全世界约有200万人发生，其特征是一生中以不可避免的，不可预测的发作方式进行骨外骨化，大多数患者只能通过轮椅将其限制在轮椅上。生命的第三个十年，需要终身护理。骨外钙化涉及韧带，肌腱，肌肉和结缔组织，导致严重的运动受限。这种情况的另一个特点是脚趾异常。诊断通常是通过临床和放射学检查做出的，但是通常建议使用Tech 99m二甲基亚甲基膦酸酯（Tc-99m MDP）骨扫描来确定疾病的程度。我们在此提出一个病例系列，其中包括四名患有这种使人衰弱的疾病的患者，他们接受了Tc99m MDP骨扫描以进行初步诊断和定位异位骨化。

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