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首页> 外文期刊>Indian Journal of Psychological Medicine >Stressful Life Events and Relapse in Bipolar Affective Disorder: A Cross-Sectional Study from a Tertiary Care Center of Southern India
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Stressful Life Events and Relapse in Bipolar Affective Disorder: A Cross-Sectional Study from a Tertiary Care Center of Southern India

机译：压力性生活事件和双相情感障碍的复发：来自印度南部三级护理中心的跨部门研究

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Background: Bipolar affective disorder (BAD) is a severe mental illness which results in serious lifelong struggles and challenges. The full impact of stressful life events (SLEs) on the course of BAD is poorly understood. Materials and Methods: A cross-sectional study was conducted on 128 consecutive patients with BAD currently admitted with a relapse. Our objectives were (1) to estimate the proportion, type, and timing of preonset SLEs in relapsed BAD patients and (2) to study the association between SLEs and selected clinical variables in this group. Semi-structured proforma, Young Mania Rating Scale, Hamilton Rating Scale for Depression, Presumptive Stressful Life Events Scale, and Brief Psychiatric Rating Scale were used. Statistical analysis was done using R software for Windows. Results: About 69.5% (89/128) of patients reported preonset SLEs – among which 50 (56.2%) had mania and 39 (43.8%) had depression. Conflict with in-laws and financial problems were the commonly reported SLEs. The mean duration between SLEs and the relapse was 19.73 ± 4.8 days. BPRS score was significantly high in subjects with preonset SLEs ( P = 0.022). No significant association was detected between SLEs and the type of episode during relapse ( P = 0.402). Conclusion: This study emphasizes the significance of SLEs in the relapse and longitudinal course of BAD. Understanding the association of SLEs and relapse in BAD will help in predicting further relapses and developing newer pharmacological and nonpharmacological measures targeting this aspect, thereby maximizing both symptom reduction and quality of life in patients with BAD.
机译：背景：双相情感障碍（BAD）是一种严重的精神疾病，导致严重的终身奋斗和挑战。人们对应激性生活事件（SLE）对BAD病程的完全影响知之甚少。材料和方法：一项横断面研究是对128例BAD患者进行的，这些患者目前均已复发。我们的目标是（1）评估复发性BAD患者中发作前SLE的比例，类型和时机;（2）研究该组SLE与所选临床变量之间的关联。使用半结构形式，青年躁狂量表，汉密尔顿抑郁量表，推定性压力生活事件量表和简短精神病量表。使用Windows的R软件进行统计分析。结果：约69.5％（89/128）的患者报告了发作前SLE –其中50（56.2％）患有躁狂症，39（43.8％）患有抑郁症。与法律上的冲突和财务问题是经常报告的SLE。 SLE和复发之间的平均持续时间为19.73±4.8天。患有先天性SLE的受试者的BPRS评分显着较高（P = 0.022）。 SLE与复发期间发作类型之间未发现显着相关性（P = 0.402）。结论：本研究强调SLE在BAD的复发和纵向过程中的意义。了解SLE与BAD复发之间的关系将有助于预测进一步的复发，并针对此方面开发更新的药理和非药理学措施，从而使BAD患者的症状减轻和生活质量最大化。

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