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首页> 外文期刊>Annals of Coloproctology >Clinical Significance of Signet-Ring-Cell Colorectal Cancer as a Prognostic Factor
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Clinical Significance of Signet-Ring-Cell Colorectal Cancer as a Prognostic Factor

机译：印戒细胞结直肠癌作为预后因素的临床意义

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Purpose The aim of this study is to evaluate the prognosis for patients with a signet-ring-cell carcinoma (SRCC) who undergo curative surgery by comparing them to patients with an adenocarcinoma (ADC), excluding a mucinous ADC. Methods Between September 1994 and December 2013, 14,110 patients with colorectal cancer underwent surgery and among them, 12,631 patients were enrolled in this study. 71 patients with a SRCC and 12,570 patients with a ADC were identified. We analyzed the disease-free survival and the overall survival rates before and after a 1:2 propensity score matching and evaluated those rates after stage stratification. Results The median follow-up durations were 48.5 months for the SRC group and 48.6 months for the ADC group. The disease-free survival rates and the overall survival rates were significantly lower in the SRC group before and after propensity score matching (P Conclusion For cancer in advanced stages, patients with a resectable colorectal SRCC had a poorer prognosis after propensity score matching than those with an ADC did. Therefore, more intensive surveillance and closer observation should be offered to such patients.
机译：目的本研究的目的是通过与根除性黏液性腺癌（ADC）除外的腺癌（ADC）患者进行比较，评估接受根治性手术的印戒细胞癌（SRCC）患者的预后。方法1994年9月至2013年12月，共对14,110例结直肠癌患者进行了手术，其中12,631例患者入选本研究。确定了71例SRCC患者和12,570例ADC患者。我们分析了1：2倾向评分匹配前后的无病生存率和总体生存率，并评估了分层后的生存率。结果SRC组中位随访时间为48.5个月，ADC组中位随访时间为48.6个月。倾向评分匹配前后，SRC组的无病生存率和总生存率均显着降低（P结论对于晚期癌症，可切除结直肠SRCC的患者倾向评分匹配后的预后较差。 ADC确实做到了，因此，应该为这类患者提供更深入的监视和更密切的观察。

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