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首页> 外文期刊>Indian Journal of Ophthalmology >Objective optical assessment of tear-film quality dynamics in patients with meibomian gland dysfunction and aqueous-deficient dry eye optical quality changes in different dry eye subtypes
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Objective optical assessment of tear-film quality dynamics in patients with meibomian gland dysfunction and aqueous-deficient dry eye optical quality changes in different dry eye subtypes

机译：客观光学评估睑板腺功能障碍和水缺乏型干眼患者不同干眼亚型的泪膜质量动态

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Purpose: To evaluate the optical quality and tear-film dynamics in patients with aqueous-deficient or evaporative subtype of dry eye disease (DED). Methods: Twenty-five aqueous-deficient dry eye (ADDE) patients, 25 DED patients with meibomian gland dysfunction (MGD), and 25 healthy subjects were included in this study. Vision-related health-targeted quality of life was evaluated using the Ocular Surface Disease Index (OSDI) questionnaire. Dynamic recording with a double-pass system (Optical Quality Analysis System [OQAS]) was performed in right eyes. Scattered light was measured as the objective scatter index (OSI) at 0.5-second intervals over 20 seconds without blinking. Then, we recorded OSI every 0.5 seconds within a 20-second period with the subjects asked to blink freely. Several parameters were established to evaluate the dynamic alterations of optical quality and the effects of blinks: OSI, OSI standard deviation (SD), ΔOSI, ΔOSI/time, blinking change (BC), and blinking frequency (BF). Additional clinical examination included tear film break-up time (BUT), Schirmer I test (SIT), fluorescein staining grade (FL), meibomian gland quality, meibomian gland expressibility, and meibomian gland drop-out. Results: The OSI, SD, ΔOSI, ΔOSI/time, BC, and BF were significantly higher in DED patients than controls (P 0.01, respectively). The OSI, SD, ΔOSI, ΔOSI/time, BC, and BF were significantly higher in patients with MGD than patients with ADDE (P 0.01). In the MGD group, BUT, FL staining score, lid abnormality, meibomian gland expressibility, and meibomian gland drop-out were correlated with Δ OSI and Δ OSI/time. Conclusion: Dry eye patients with MGD had significant alterations of optical quality compared with ADDE patients. The double-pass system has potential to be a useful quantitative method to evaluate the optical quality and tear-film dynamics in patients with dry eye.
机译：目的：评估患有水缺乏或蒸发性干眼病（DED）的患者的光学质量和泪膜动力学。方法：本研究纳入了25例缺水性干眼症（ADDE）患者，25例睑板腺功能障碍（MGD）患者和25例健康受试者。使用眼表疾病指数（OSDI）问卷评估了与视觉有关的健康目标生活质量。右眼使用双通道系统（光学质量分析系统[OQAS]）进行动态记录。在20秒内以0.5秒的间隔测量散射光作为目标散射指数（OSI），并且不闪烁。然后，我们在20秒内每0.5秒记录一次OSI，要求被试自由眨眼。建立了几个参数来评估光学质量的动态变化和眨眼的影响：OSI，OSI标准差（SD），ΔOSI，ΔOSI/时间，眨眼变化（BC）和眨眼频率（BF）。其他临床检查包括泪膜破裂时间（BUT），Schirmer I测试（SIT），荧光素染色等级（FL），睑板腺质量，睑板腺可表达性和睑板腺脱落。结果：DED患者的OSI，SD，ΔOSI，ΔOSI/ time，BC和BF显着高于对照组（分别为P <0.01）。 MGD患者的OSI，SD，ΔOSI，ΔOSI/时间，BC和BF显着高于ADDE患者（P <0.01）。在MGD组中，BUT，FL染色评分，眼睑异常，睑板腺表达能力和睑板腺脱落与ΔOSI和ΔOSI /时间相关。结论：与ADDE患者相比，MGD的干眼患者的光学质量有显着改变。双通道系统有可能成为评估干眼患者的光学质量和泪膜动力学的有用定量方法。

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