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首页> 外文期刊>Indian Journal of Pathology and Microbiology >Significance of vascular endothelial growth factor and CD31 and morphometric analysis of microvessel density by CD31 receptor expression as an adjuvant tool in diagnosis of psoriatic lesions of skin
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Significance of vascular endothelial growth factor and CD31 and morphometric analysis of microvessel density by CD31 receptor expression as an adjuvant tool in diagnosis of psoriatic lesions of skin

机译：血管内皮细胞生长因子和CD31的表达以及CD31受体表达对微血管密度的形态分析作为辅助工具诊断皮肤银屑病的意义

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Background: Pathogenesis of psoriasis is a debated issue. Several mechanisms have been proposed to identify the etiology and pathogenesis so that specific treatments can be given to patients with psoriasis. Aims: (1) To compare pattern and distribution of vascular endothelial growth factor (VEGF) and CD31 in patients with psoriasis and other psoriasiform lesions of skin. (2) To study the correlation between VEGF and CD31 expression, clinical severity, and histopathology of psoriasiform lesions of skin. (3) Evaluation of microvessel density (MVD) by using computer-assisted quantitative image analysis in psoriatic skin lesions. Materials and Methods: This study was conducted on eighty cases, out of which forty were diagnosed cases of psoriasis and forty cases of clinically suspected psoriasiform lesions, submitted in the Department of Pathology, Pt. B.D. Sharma, University of Health Sciences, Rohtak, for histopathological examination. Histopathological sections were stained by routine hematoxylin and eosin staining, and these biopsies were further subjected to immunohistochemical staining with VEGF and CD31 as per standard technique. Results: Assessment of various histopathological features revealed strong correlation between epidermal hyperplasia, suprapapillary thinning, and elongation of rete ridges. Suprabasilar keratinocytes in psoriatic lesions stained intensely for VEGF. The difference for number of microvessels and MVD in psoriasis and psoriasiform lesions was statistically significant. Correlation between intensity of VEGF staining by suprabasilar keratinocytes and MVD was found to be highly significant in psoriatic lesions. Conclusion: The present study concluded that psoriatic lesions exhibit potent angiogenic activity. Early lesions show increased MVD along with other histomorphological parameters such as hypogranulosis, parakeratosis and Munro's microabscesses. Overexpression of VEGF by suprabasilar keratinocytes correlated with increased MVD in papillary dermis.
机译：背景：牛皮癣的发病机制是一个有争议的问题。已经提出了几种机制来鉴定病因和发病机理，以便可以对牛皮癣患者进行特定的治疗。目的：（1）比较牛皮癣和其他牛皮癣样皮肤病患者的血管内皮生长因子（VEGF）和CD31的模式和分布。 （2）研究皮肤牛皮癣样病变的VEGF与CD31表达，临床严重程度及组织病理学之间的关系。 （3）通过计算机辅助定量图像分析对银屑病皮肤病变的微血管密度（MVD）进行评估。资料和方法：本研究针对80例病例进行，其中40例确诊为牛皮癣病例，40例临床怀疑为银屑病样病变，已在Pt病理学部门提交。公元前Sharma，Rohtak卫生科学大学，进行组织病理学检查。通过常规苏木精和曙红染色对组织病理切片进行染色，然后按照标准技术对这些活检组织进行VEGF和CD31免疫组织化学染色。结果：对各种组织病理学特征的评估显示，表皮增生，乳头上变薄和网状脊伸长之间密切相关。银屑病皮损中的基底上角质形成细胞的VEGF染色强烈。银屑病和牛皮癣样病变中微血管和MVD数量的差异具有统计学意义。发现银屑病性皮层上角质形成细胞的VEGF染色强度与MVD之间的相关性非常高。结论：本研究得出结论，银屑病皮损表现出有效的血管生成活性。早期病变显示MVD增高，并伴有其他组织形态学参数，例如肉芽肿少，角化不全和Munro微脓肿。乳突上角化细胞过度表达VEGF与乳头状真皮中MVD增加有关。

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