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首页> 外文期刊>Indian Journal of Pathology and Microbiology >Therapy related myelodysplastic syndrome: A case report and review of literature
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Therapy related myelodysplastic syndrome: A case report and review of literature

机译：与治疗相关的骨髓增生异常综合征：一例病例报告并文献复习

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Therapy related myeloid neoplasm is directly related to previous cytotoxic chemotherapy or radiation therapy. We present a 47-year-old lady who developed therapy related myelodysplastic syndrome (MDS) 2.5 years after she received four cycles of chemotherapy and local radiation therapy for carcinoma breast. She presented with bicytopenia with trilineage dyspoiesis in the peripheral blood, bone marrow aspirate and biopsy. Fluorescent in-situ hybridization studies did not reveal any of the common abnormalities associated with MDS. A diagnosis of therapy related MDS was rendered. Different studies have shown that patients treated with alkylating agents and ionizing radiation present as MDS with a latent period of 3-10 years. Our patient developed MDS within 2.5 years of starting chemotherapy and radiotherapy and did not reveal any of the conventional cytogenetic abnormalities. It highlights the importance of simple tests like a complete blood count and peripheral blood smear examination in follow-up of the patients treated with chemotherapy.
机译：与治疗有关的骨髓瘤与先前的细胞毒性化学疗法或放射疗法直接相关。我们介绍了一位47岁的女士，她在接受了四个周期的乳腺癌化疗和局部放疗后2.5年出现了与治疗相关的骨髓增生异常综合症（MDS）。她表现为双血细胞减少症，外周血，骨髓穿刺活检和三联性发育不良。荧光原位杂交研究未发现与MDS相关的任何常见异常。对与治疗有关的MDS进行了诊断。不同的研究表明，用烷基化剂和电离辐射治疗的患者作为MDS的潜伏期为3-10年。我们的患者在开始化疗和放疗后的2.5年内出现了MDS，并且没有发现任何常规的细胞遗传学异常。它强调了简单的检查（如全血细胞计数和外周血涂片检查）在接受化疗的患者的随访中的重要性。

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