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首页> 外文期刊>Indian Journal of Pathology and Microbiology >Detection of HIV drug resistance mutations in pregnant women receiving single dose Nevirapine in south India
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Detection of HIV drug resistance mutations in pregnant women receiving single dose Nevirapine in south India

机译：印度南部接受单剂量奈韦拉平孕妇的HIV耐药性突变检测

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Background: Single dose of Nevirapine to prevent mother to child transmission of HIV is the commonest preventive regimen in resource-limited countries. Objectives: The objective of this study was to detect drug-resistant virus after single dose of Nevirapine (sdNVP) provided to delivering HIV seropositive (HIV+ve) women and to evaluate the time taken for its decay. Results: Of the 36 consenting HIV+ve pregnant women enrolled into the study, the mean hemoglobin and total lymphocyte counts were 10.8 g/dl and 1843 cells/mm 3 , respectively. Mean CD4 counts in 64% of women was 363 cells/mm 3 and mean viral load for 16/36 women was 28,143 copies/ml of plasma. Nevirapine-resistance mutations were detected in 28% of women at delivery; using OLA (Oligonucleotide Ligation Assay). K103N mutations were seen in 19.4% of women while the Y181C mutation was seen in 5%. Both the mutations were detected in 2.7% of women. Sequential blood samples collected at delivery, 7-10 days, 6 weeks, 4 months, 6 months and one year postpartum showed that 81% of K103N mutations and 66.7% of Y181C mutations were detected at 6 weeks postpartum . Wild-type virus had replaced the mutants by one year postpartum in all women except one. Conclusion : These observations are relevant for future treatment with antiretroviral therapy in these women for their HIV disease.
机译：背景：在资源有限的国家中，单剂量奈韦拉平预防母婴传播艾滋病毒是最常见的预防方案。目的：本研究的目的是在向HIV血清阳性（HIV + ve）妇女提供单剂量的奈韦拉平（sdNVP）后检测耐药病毒，并评估其衰减所需的时间。结果：纳入研究的36名同意接受HIV + ve的孕妇中，平均血红蛋白和总淋巴细胞计数分别为10.8 g / dl和1843细胞/ mm 3 。 64％妇女的平均CD4计数为363细胞/ mm 3 ，16/36妇女的平均病毒载量为28,143拷贝/ ml血浆。分娩时在28％的妇女中检测到耐奈韦拉平的突变;使用OLA（寡核苷酸连接测定法）。在19.4％的女性中观察到K103N突变，而在5％的女性中观察到Y181C突变。在2.7％的女性中检测到两种突变。在分娩后，分娩后7-10天，6周，4个月，6个月和1年收集的顺序血液样本显示，在分娩后6周检测到81％的K103N突变和66.7％的Y181C突变。除一名女性外，所有妇女在产后一年都用野生型病毒替代了突变体。结论：这些观察结果与这些妇女因艾滋病毒而接受抗逆转录病毒疗法的未来治疗有关。

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