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Host and Virus Protein Interaction Studies in Understanding Shrimp Virus Gene Function

机译:宿主和病毒蛋白相互作用研究以了解虾病毒基因功能

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Protein–protein interaction studies have been widely used in several fields to characterize an unknown protein. This in turn helps to find out several pathways to understand a complex mechanism or discover a drug for treatment. Among the methods, yeast two-hybrid has widely been used in human, animal and plant research studies. This aspect of research has also been found useful in understanding the shrimp virus gene function. With respect to White spot syndrome virus, interaction studies have been applied to elucidate virus structure, understand the mode of entry of the virus, mechanism of virus replication and also to discover some of the host anti-viral proteins. Interaction studies on other shrimp viruses are scanty and only few reports available on Yellow head virus and Taura syndrome virus. All these findings are still in preliminary stage and lot more studies are necessary to have the clear picture. Protein interaction research on other shrimp viruses are still lacking. Considering all these, it appears that this field of research has a wide scope to understand the virulence mechanism of shrimp viruses where very little information is available till date.
机译:蛋白质间相互作用研究已广泛应用于几个领域,以鉴定未知蛋白质。反过来,这有助于找出几种途径来了解复杂的机制或发现用于治疗的药物。在这些方法中,酵母双杂交已广泛用于人类,动物和植物的研究。研究的这一方面也被发现有助于理解虾病毒基因功能。对于白斑综合症病毒,已经进行了相互作用研究来阐明病毒的结构,了解病毒的进入方式,病毒复制的机制以及发现一些宿主抗病毒蛋白。其他虾病毒的相互作用研究很少,关于黄头病毒和Taura综合征病毒的报道很少。所有这些发现仍处于初步阶段,需要更多的研究才能清楚地了解情况。仍缺乏其他虾病毒的蛋白质相互作用研究。综合考虑所有这些因素,似乎该研究领域具有广泛的了解虾病毒的毒力机制的能力,而迄今为止迄今为止几乎没有任何信息。

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