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首页> 外文期刊>Infectious Agents and Cancer >HLA polymorphisms and detection of kaposi sarcoma-associated herpesvirus DNA in saliva and peripheral blood among children and their mothers in the uganda sickle cell anemia KSHV Study
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HLA polymorphisms and detection of kaposi sarcoma-associated herpesvirus DNA in saliva and peripheral blood among children and their mothers in the uganda sickle cell anemia KSHV Study

机译：乌干达镰刀细胞性贫血中儿童及其母亲的唾液和外周血中的HLA基因多态性和卡波氏肉瘤相关疱疹病毒DNA的检测KSHV研究

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Kaposi sarcoma-associated herpesvirus (KSHV, also called Human herpesvirus 8 or HHV8) is a γ-2 herpesvirus that causes Kaposi sarcoma. KSHV seroprevalence rates vary geographically with variable rates recorded in different sub Sahara African countries, suggesting that effects of genetic and/or environmental factors may influence the risk of infection. One study conducted in South Africa, where KSHV seroprevalence is relatively low, found that carriage of human leukocyte antigen (HLA) alleles HLA-A*6801, HLA-A*30, HLA-A*4301, and HLA-DRB1*04 was associated with increased shedding of KSHV DNA in saliva. Confirmation of those results would strengthen the hypothesis that genetic factors may influence KSHV distribution by modulating KSHV shedding in saliva. To explore these associations in another setting, we used high resolution HLA-A, B, and DRB1 typing on residual samples from the Uganda Sickle Cell Anemia KSHV study, conducted in a high KSHV seroprevalence region, to investigate associations between HLA and KSHV shedding in saliva or peripheral blood among 233 children and their mothers. HLA-A and HLA-DRB1 alleles were not associated with KSHV shedding in our study, but our study was small and was not adequately powered to exclude small associations. In exploratory analyses, we found marginal association of KSHV DNA shedding in saliva but not in peripheral blood among children carrying HLA- B*4415 and marginal association of KSHV DNA shedding in peripheral blood but not in saliva among children carrying HLA- B*0801 alleles. The contribution of individual HLA polymorphisms to KSHV shedding is important but it may vary in different populations. Larger population-based studies are needed to estimate the magnitude and direction of association of HLA with KSHV shedding and viral control.
机译：卡波西氏肉瘤相关疱疹病毒（KSHV，也称为人疱疹病毒8或HHV8）是引起卡波西氏肉瘤的γ-2疱疹病毒。在不同的撒哈拉以南非洲国家，KSHV的血清阳性率随地理位置的变化而变化，这表明遗传和/或环境因素的影响可能会影响感染的风险。在南非，其中KSHV血清阳性率较低的一项研究发现，人类白细胞抗原（HLA）等位基因HLA-A * 6801，HLA-A * 30，HLA-A * 4301和HLA-DRB1 * 04的携带是与唾液中KSHV DNA脱落增加有关。对这些结果的证实将加强以下假设：遗传因素可通​​过调节唾液中的KSHV脱落而影响KSHV分布。为了在另一种情况下探索这些关联，我们对来自乌干达镰刀细胞性贫血KSHV研究的残留样品进行了高分辨率HLA-A，B和DRB1分型，该研究在高KSHV血清阳性率区域进行，以调查HLA和KSHV脱落之间的关联。 233名儿童及其母亲的唾液或外周血。在我们的研究中，HLA-A和HLA-DRB1等位基因与KSHV脱落无关，但我们的研究规模很小，没有足够的能力排除小的关联。在探索性分析中，我们发现携带HLA-B * 4415的儿童唾液中KSHV DNA脱落的边缘相关，但未检测到外周血;而携带HLA-B * 0801等位基因的儿童中唾液中KSHV DNA的边缘相关而不是唾液。 。单个HLA多态性对KSHV脱落的贡献很重要，但在不同人群中可能有所不同。需要进行更多的基于人群的研究，以估计HLA与KSHV脱落和病毒控制的关联的程度和方向。

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