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首页> 外文期刊>Infectious Diseases and Therapy >Clinical and Economic Burden of Hepatic and Extrahepatic Complications from Chronic Hepatitis C: A Retrospective Analysis of German Sickness Fund Data
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Clinical and Economic Burden of Hepatic and Extrahepatic Complications from Chronic Hepatitis C: A Retrospective Analysis of German Sickness Fund Data

机译：慢性丙型肝炎引起的肝内和肝外并发症的临床和经济负担：德国疾病基金数据的回顾性分析

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IntroductionGerman data regarding the burden of complications from chronic hepatitis C (CHC) virus infection are limited. To address this issue, this study evaluates the clinical and economic burden of hepatic and extrahepatic complications (EHCs) associated with CHC in Germany. MethodsThis retrospective, cross-sectional study used claims data from the Betriebskrankenkasse German sickness fund (2007–2014) to assess the risks and medical costs of hepatic complications and EHCs, including conditions that are prevalent and behavioral factors associated with CHC. Prevalence, incidence, and risks were calculated for 1:1 matched patients with and without CHC ( n =?3994). All-cause cost, medical costs related to hepatic and EHCs, as well as CHC-related and non-CHC-related pharmacy costs (adjusted to the 2016 Euro rate), were calculated and compared between 1:5 matched patients with ( n =?8425) and without CHC ( n =?42,125). ResultsPatients with CHC had a 3-fold higher risk for any EHC (OR?=?3.0; P ConclusionCHC is associated with substantial clinical and economic burden in Germany, largely due to hepatic complications and EHCs. FundingAbbvie Inc.
机译：简介关于慢性丙型肝炎（CHC）病毒感染并发症负担的德国数据有限。为了解决这个问题，本研究评估了德国与CHC相关的肝和肝外并发症（EHC）的临床和经济负担。方法：这项回顾性横断面研究使用了德国疾病基金会（Betriebskrankenkasse）的疾病索赔数据（2007-2014年）来评估肝并发症和EHC的风险和医疗费用，包括普遍存在的疾病和与CHC相关的行为因素。计算了有和没有CHC的1：1匹配患者的患病率，发生率和风险（n =？3994）。计算并比较了1：5匹配的患者中所有原因成本，与肝脏和EHC相关的医疗成本以及CHC相关和非CHC相关的药房成本（根据2016欧元汇率调整）。 ≤8425）而没有CHC（n =≤42,125）。结果患有CHC的患者发生任何EHC的风险高3倍（OR≥3.0）; P结论在德国，CHC与大量的临床和经济负担有关，这主要归因于肝脏并发症和EHC。

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