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首页> 外文期刊>Infectious Diseases and Therapy >Systematic Review of Invasive Meningococcal Disease: Sequelae and Quality of Life Impact on Patients and Their Caregivers
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Systematic Review of Invasive Meningococcal Disease: Sequelae and Quality of Life Impact on Patients and Their Caregivers

机译：侵袭性脑膜炎双球菌疾病的系统评价：后遗症和生活质量对患者及其护理人员的影响

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IntroductionInvasive meningococcal disease (IMD, septicaemia and/or meningitis) has a severe acute and long-term burden: 5–10% of patients die within 48?h, and long-term sequelae have been reported in 10–20% of survivors. Health-related quality of life (HRQoL) is increasingly but inconsistently assessed. MethodsA systematic literature review on Neisseria meningitidis IMD sequelae and HRQoL in survivors of all ages and their caregivers, including family, was conducted for high-income countries from 2001 to 2016 (in Medline and Embase, following Cochrane and PRISMA guidelines). ResultsA total of 31 studies, mostly of childhood IMD cases, were included. A broad range of physical, neurological and psychological IMD sequelae were identified. The literature has evolved, with more types of sequelae reported in more recent studies; however, meningococcal disease-specific and sequelae-specific HRQoL data are lacking, and existing studies used a wide variety of instruments. Physical sequelae included: amputations (up to 8% of children, 3% adolescents/adults) and skin scars (up to 55% of children, 18% adolescents, 2% adults). Neurologic sequelae included: hearing loss (up to 19% of infants, 13% children, 12% adolescents, 8% adults). Psychological sequelae included: anxiety, learning difficulties, emotional and behavioural difficulties. IMD negatively affects HRQoL in patients and also in their family and close caregiver network, both in the short- and long-term. Even IMD survivors without sequelae experienced an adverse impact on HRQoL after many years, affecting self-esteem, physical, mental and psychosocial health, and HRQoL was worse in those with cognitive and behavioural sequelae. ConclusionA high proportion of IMD survivors are affected by a broad range of sequelae and reduced HRQoL that persists years after infection. Childhood IMD survivors had more sequelae and more severe sequelae compared with adult survivors. HRQoL was affected in patients and also in their families, caregivers and surrounding network over the long term. More research is needed to resolve data gaps and to standardise HRQoL assessment. FundingGlaxoSmithKline Biologicals SA (Rixensart, Belgium).
机译：简介侵袭性脑膜炎球菌病（IMD，败血病和/或脑膜炎）具有严重的急性和长期负担：5-10％的患者在48小时内死亡，据报道有10-20％的幸存者患有长期后遗症。与健康相关的生活质量（HRQoL）越来越多，但评估不一致。方法2001年至2016年，针对高收入国家（包括Cochrane和PRISMA指南，在Medline和Embase中）针对高收入国家/地区的所有年龄段的幸存者及其照顾者（包括家庭）的脑膜炎奈瑟菌IMD后遗症和HRQoL进行了系统的文献综述。结果共纳入31项研究，其中大部分是儿童IMD病例。确定了广泛的生理，神经和心理IMD后遗症。文献已经发展，最近的研究报道了更多类型的后遗症。但是，缺乏针对脑膜炎球菌疾病和后遗症的HRQoL数据，现有研究使用了各种各样的仪器。身体后遗症包括：截肢（最多8％的儿童，3％的青少年/成人）和皮肤疤痕（最多55％的儿童，18％的青少年，2％的成年人）。神经系统后遗症包括：听力下降（多达19％的婴儿，13％的儿童，12％的青少年，8％的成年人）。心理后遗症包括：焦虑，学习困难，情绪和行为困难。在短期和长期内，IMD都会对患者以及他们的家庭和密切的照护者网络的HRQoL产生负面影响。即使是没有后遗症的IMD幸存者，多年后也会对HRQoL产生不利影响，影响自尊，身体，心理和心理社会健康，而患有认知和行为后遗症的人的HRQoL更为严重。结论感染后数年内，很大比例的后遗症和HRQoL降低影响了IMD幸存者的比例。与成年幸存者相比，儿童IMD幸存者的后遗症更多，后遗症更为严重。长期而言，HRQoL在患者及其家人，护理人员和周围网络中受到影响。需要更多的研究来解决数据差距和标准化HRQoL评估。资金葛兰素史克生物制药公司（比利时里森萨特）。

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