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首页> 外文期刊>Infectious Diseases and Therapy >The H3 Haplotype of the EPCR Gene Determines High sEPCR Levels in Critically Ill Septic Patients
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The H3 Haplotype of the EPCR Gene Determines High sEPCR Levels in Critically Ill Septic Patients

机译：EPCR基因的H3单倍型确定重症脓毒症患者的sEPCR水平高

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IntroductionA soluble (s) form of the endothelial protein C receptor (EPCR) circulates in plasma and inhibits activated protein C (APC) activities. The clinical impact of sEPCR and its involvement in the septic process is under investigation. This study determined the frequencies of EPCR haplotypes H1 and H3 to investigate possible associations with plasma admission levels of sEPCR in an intensive care unit (ICU) cohort of septic patients. MethodsThree polymorphisms in the EPCR gene were genotyped in 239 Caucasian critically ill patients, and their plasma sEPCR levels were also measured at the time of admission to the ICU. Multivariate logistic regression analysis controlling for sepsis severity, age, acute physiology and chronic health evaluation (APACHE II) and sequential organ failure assessment (SOFA) scores, lactate level, sex, diagnostic category, length of ICU stay and hospital mortality was performed to determine the effect of EPCR haplotypes H1 and H3 on the levels of sEPCR. ResultsIndividuals carrying at least one H3 allele had significantly higher levels of sEPCR than individuals with no H3 alleles ( p ConclusionUsing the preceding and current sepsis definitions, sEPCR levels and the H3 haplotype were not associated with sepsis severity and the risk of poor outcomes in septic patients; however, the EPCR H3 allele contributed to higher levels of sEPCR.
机译：简介内皮蛋白C受体（EPCR）的可溶形式在血浆中循环并抑制活化的蛋白C（APC）活性。 sEPCR的临床影响及其在败血过程中的作用正在研究中。这项研究确定了EPCR单倍型H1和H3的频率，以研究与脓毒症患者的重症监护病房（ICU）队列中sEPCR的血浆入院水平之间的可能联系。方法对239名白种人危重病人EPCR基因的3个基因型进行基因分型，并在入ICU时测定其血浆sEPCR水平。进行了控制败血症严重程度，年龄，急性生理和慢性健康评估（APACHE II）和序贯器官衰竭评估（SOFA）得分，乳酸水平，性别，诊断类别，ICU住院时间和住院死亡率的多元逻辑回归分析，以确定EPCR单倍型H1和H3对sEPCR水平的影响。结果携带至少一个H3等位基因的人的sEPCR水平要比没有H3等位基因的人高得多（p结论根据先前和当前的脓毒症定义，sEPCR水平和H3单倍型与败血症的严重程度以及败血症患者预后不良的风险无关;然而，EPCR H3等位基因促成了更高水平的sEPCR。

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