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首页> 外文期刊>Infection and Drug Resistance >Antimicrobial activities of ceftazidime–avibactam, ceftolozane–tazobactam, and other agents against Escherichia coli , Klebsiella pneumoniae , and Pseudomonas aeruginosa isolated from intensive care units in Taiwan: results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan in 2016
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Antimicrobial activities of ceftazidime–avibactam, ceftolozane–tazobactam, and other agents against Escherichia coli , Klebsiella pneumoniae , and Pseudomonas aeruginosa isolated from intensive care units in Taiwan: results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan in 2016

机译：头孢他啶-avibactam，头孢洛氮烷-他唑巴坦和其他药物对台湾加护病房中分离的大肠杆菌，肺炎克雷伯菌和铜绿假单胞菌的抗菌活性：2016年台湾多中心抗菌素耐药性监测结果

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Objective: The aim of this study was to investigate the in vitro antimicrobial susceptibilities of clinically important Gram-negative bacteria from seven intensive care units in Taiwan in 2016. Materials and methods: In total, 300 non-duplicate isolates of Escherichia coli (n=100), Klebsiella pneumoniae (n=100), and Pseudomonas aeruginosa (n=100) collected from 300 patients were studied. The minimum inhibitory concentrations (MICs) of these isolates to antimicrobial agents were determined using the broth microdilution method. Carbapenemase-encoding genes ( bla subKPC/sub, bla subNDM/sub, bla subIMP/sub, bla subVIM/sub, and bla subOXA-48-like/sub) were studied for the isolates that were not susceptible to any carbapenems. Sequencing analysis of the mcr genes ( mcr -1–5) was conducted for all isolates with colistin MICs ≥4 mg/L. Results: Ertapenem non-susceptibility was detected in 3% (n=3) E. coli and 12% (n=12) K.?-pneumoniae isolates. The susceptibility rates of imipenem, ceftazidime–avibactam (CAZ–AVB), and ceftolozane–tazobactam (CLZ–TAZ) were 99%, 99%, and 88%, respectively, for E. coli , 91%, 100%, and 80%, respectively, for K. pneumoniae , and 66%, 91%, and 93%, respectively, for P. aeruginosa . Carbapenemase-encoding genes were not detected in E. coli , were detected in four (33.3%) K. pneumoniae isolates that were not susceptible to ertapenem (three harboring bla subKPC/sub and one harboring bla subOXA-48-like/sub), and were not detected in P. aeruginosa isolates that were not susceptible to imipenem. One K. pneumoniae isolate was resistant to colistin (MIC 4 mg/L) and negative for mcr genes. Conclusion: CAZ–AVB exhibited excellent activity against carbapenem-resistant Enterobacteriaceae , and CLZ–TAZ exhibited good activity against imipenem-resistant P. aeruginosa .
机译：目的：本研究旨在调查2016年台湾七个重症监护病房临床上重要的革兰氏阴性细菌的体外抗菌药敏性。材料与方法：共有300株非重复性大肠杆菌（n = 100例），肺炎克雷伯菌（n = 100）和铜绿假单胞菌（n = 100）从300例患者中进行了研究。使用肉汤微稀释法确定这些分离物对抗菌剂的最低抑制浓度（MIC）。碳青霉烯酶编码基因（bla KPC ，bla NDM ，bla IMP ，bla VIM 和bla 研究了不敏感于碳青霉烯类的分离物OXA-48-like 。对所有粘菌素MIC≥4mg / L的菌株进行了mcr基因（mcr -1–5）的测序分析。结果：在3％（n = 3）的大肠杆菌和12％（n = 12）的K.α-肺炎分离株中检出了厄他培南的非药敏性。亚胺培南，头孢他啶-avibactam（CAZ-AVB）和头孢唑烷-他唑巴坦（CLZ-TAZ）的敏感性分别为99％，99％和88％，其中大肠杆菌分别为91％，100％和80肺炎克雷伯氏菌分别为5％，铜绿假单胞菌分别为66％，91％和93％。在大肠杆菌中未检测到碳青霉烯酶编码基因，在四个不易患厄他培南的肺炎克雷伯菌分离物中检测到了碳青霉烯酶编码基因（其中三个含有bla KPC ，一个含有bla OXA -48-like ），并且在对亚胺培南不敏感的铜绿假单胞菌分离物中未检测到。一种肺炎克雷伯菌分离株对大肠菌素有抵抗力（MIC 4 mg / L），而对mcr基因呈阴性。结论：CAZ-AVB对耐碳青霉烯的肠杆菌科细菌具有优异的活性，而CLZ-TAZ对耐亚胺培南的铜绿假单胞菌具有良好的活性。

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