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首页> 外文期刊>Influenza and other respiratory viruses. >Genetic characterization of influenza virus circulating in Brazilian pigs during 2009 and 2010 reveals a high prevalence of the pandemic H1N1 subtype
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Genetic characterization of influenza virus circulating in Brazilian pigs during 2009 and 2010 reveals a high prevalence of the pandemic H1N1 subtype

机译：2009年和2010年在巴西猪中传播的流感病毒的遗传特征表明，大流行H1N1亚型的流行率很高

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AbstractBackgroundInfluenza A viruses circulating in pigs in Brazil are still not characterized, and only limited data are available about swine influenza epidemiology in the country. Therefore, we characterized the hemagglutinin (HA) and neuraminidase (NA) genes of influenza viruses isolated from Brazilian pigs. We also evaluated one case of probable swine-to-human transmission.MethodsTwenty influenza viruses isolated from pigs during 2009–2010 in five Brazilian states (Minas Gerais, Sao Paulo, Parana, Rio Grande do Sul, and Mato Grosso) were used. One human isolate, from a technician who became ill after visiting a swineherd going through a respiratory disease outbreak, was also used in the study. Phylogenetic analysis for the HA and NA genes and hemagglutinin amino acid sequence alignment were performed.ResultsAll isolates clustered with pandemic H1N1 2009 (pH1N1) viruses and appeared to have a common ancestor. Genetic diversity was higher in the HA than in the NA gene, and the amino acid substitution S203T in one of HA's antigenic sites was found in most of the samples. The human isolate was more related to swine isolates from the same herd visited by the technician than to other human isolates, suggesting swine-to-human transmission.ConclusionOur results show that pH1N1 was disseminated and the predominant subtype in Brazilian pigs in 2009–2010.
机译：摘要目前尚无巴西猪中传播的甲型流感病毒的特征，只有关于该国猪流感流行病学的数据有限。因此，我们表征了从巴西猪分离的流感病毒的血凝素（HA）和神经氨酸酶（NA）基因的特征。我们还评估了1例可能的猪对人传播的病例。方法2009年至2010年期间，在巴西的五个州（米纳斯吉拉斯州，圣保罗，巴拉那州，南里奥格兰德州和马托格罗索州）从猪中分离出20种流感病毒。这项研究还使用了一个人隔离株，该人来自探访了经历过呼吸道疾病爆发的猪群后生病的技术人员。结果对所有分离株均以大流行H1N1 2009（pH1N1）病毒进行了聚类，并且似乎具有共同的祖先。 HA中的遗传多样性高于NA基因中的遗传多样性，并且在大多数样品中发现了HA抗原位点之一的氨基酸取代S203T。人类分离株与技术人员拜访的同一群猪分离株之间的相关性高于其他人类分离株，表明猪对人之间的传播。结论我们的结果表明，在2009–2010年间，pH1N1在巴西猪中传播并且占主导地位。

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