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首页> 外文期刊>Influenza and other respiratory viruses. >Comparisons of oseltamivir‐resistant (H275Y) and concurrent oseltamivir‐susceptible seasonal influenza A(H1N1) virus infections in hospitalized adults, 2008–2009
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Comparisons of oseltamivir‐resistant (H275Y) and concurrent oseltamivir‐susceptible seasonal influenza A(H1N1) virus infections in hospitalized adults, 2008–2009

机译：2008-2009年住院成人抗奥司他韦（H275Y）和奥司他韦敏感性季节性季节性流感A（H1N1）病毒感染的比较

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摘要

AbstractIn an observational cohort study, we found that adults hospitalized for oseltamivir-resistant (H275Y) seasonal H1N1 influenza (n = 46) were older than those infected with oseltamivir-susceptible strains (n = 31) [74(IQR 59–83) versus 64(IQR 48–76) years; P = 0·045], and most had major comorbidities (78% versus 65%). Disease severity and clinical outcomes were comparable between the two groups: radiographic pneumonia 40–42%, supplemental oxygen use 47–48%, critical illness 11–13%, median duration of hospitalization 5–6 days, death rate 6–9%. Failure to receive effective antiviral therapy was associated with progression to critical illness (23% versus 0%, P = 0·016) and death (20% versus 0%, P = 0·033) in hospitalized patients with seasonal H1N1 influenza.
机译：摘要在一项观察性队列研究中，我们发现因奥司他韦耐药（H275Y）季节性H1N1流感住院（n = 46）的成年人比被奥司他韦敏感菌株（n = 31）感染的成年人[74（IQR 59-83）与64（IQR 48-76）年; P = 0·045]，大多数合并症很严重（78％比65％）。两组之间的疾病严重程度和临床结果相当：放射线性肺炎40-42％，补充氧气使用47-48％，危重疾病11-13％，中位住院时间5-6天，死亡率6-9％。在季节性H1N1流感住院患者中，未能接受有效的抗病毒治疗与进展为重症疾病（23％vs 0％，P = 0.016）和死亡（20％vs 0％，P = 0.033）有关。

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