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首页> 外文期刊>Influenza and other respiratory viruses. >Estimates of influenza‐associated hospitalisations in tropical Singapore, 2010‐2017: Higher burden estimated in more recent years
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Estimates of influenza‐associated hospitalisations in tropical Singapore, 2010‐2017: Higher burden estimated in more recent years

机译：2010-2017年新加坡热带地区与流感相关的住院估计：近年来估计更高的负担

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Background We previously estimated Singapore's influenza‐associated hospitalisation rate for pneumonia and influenza (P&I) in 2010‐2012 to be 29.6 per 100?000 person‐years, which corresponds to 11.2% of all P&I hospitalisations. Objectives This study aims to update Singapore's estimates of the influenza‐associated pneumonia and influenza (P&I) hospitalisation burden using the latest data from 2010 to 2017. Methods We estimated the number of P&I hospitalisations associated with influenza using generalised additive models. We specified the weekly number of admissions for P&I and the weekly influenza positivity in the models, along with potential confounders such as weekly respiratory syncytial virus (RSV) positivity and meteorological data. Results In 2010‐2017, 16.3% of all P&I hospitalisations in Singapore were estimated to be attributed to influenza, corresponding to an excess influenza‐associated P&I hospitalisation rate of 50.1 per 100?000 person‐years. Higher excess rates were estimated for children aged 0‐4?years (186.8 per 100?000 person‐years) and elderly aged?≥?65?years (338.0 per 100?000 person‐years). Higher influenza‐associated hospitalisation rates were estimated for 2016 and 2017 (67.9 and 75.1 per 100?000 persons, respectively) years when the influenza A(H3N2) subtype was dominant. Conclusion Influenza burden in Singapore has increased since 2010. Influenza vaccination programmes should continue to be prioritised for the young and the elderly.
机译：背景我们之前估计，新加坡在2010-2012年间与流感相关的肺炎和流感（P＆I）住院率为每10万人年29.6，相当于所有P＆I住院率的11.2％。目的本研究旨在使用2010年至2017年的最新数据来更新新加坡对流感相关的肺炎和流感（P＆I）住院负担的估计。方法我们使用广义加性模型估计了与流感相关的P＆I住院人数。我们在模型中指定了P＆I的每周入院数和每周的流感阳性率，以及潜在的混淆因素，例如每周呼吸道合胞病毒（RSV）阳性和气象数据。结果在2010-2017年，新加坡所有P＆I住院病例中，估计有16.3％归因于流感，相当于每100000人年50.1例与流感相关的P＆I住院率过高。估计0-4岁儿童的过高发生率更高（每100000人年186.8）和65岁以上≥65岁的老人（每100000人年338.0）。在甲型（H3N2）流感占主导地位的2016年和2017年，与流感相关的住院率估计较高（分别为每100000人67.9和75.1）。结论自2010年以来，新加坡的流感负担有所增加。应继续优先考虑年轻人和老年人的流感疫苗接种计划。

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